Synthetic Versatility of 2-Oxazolone Heterocycle for Stereo-controlled Construction of 2-Amino Alcohols

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概要

• 論文の詳細を見る

• Synthetic potential of the simple heterocycle, 2-oxazolone, as a building block for 2-amino alcohols has been reviewed. Stereodefined introduction of easily replaceable groups to the olefinic moiety of the 2-oxazolone ring, followed by stereospecific and stepwise substitution, works well as a versatile strategy for the chiral synthesis of a wide variety of 2-amino alcohols of biological interest. Sterically constrained chiral 2-oxazolidinones and the derived 2-amino alcohols which are derived from cycloaddition of the 2-oxazolone to cyclic dienes such as anthracenes and cyclopentadiene have general use as excellent auxiliaries and ligands in asymmetric synthesis.

• 社団法人 有機合成化学協会の論文
• 1997-11-01

著者

• KUNIEDA Takehisa

  Faculty of Pharmaceutical Sciences, Sojo University

• Ishizuka Tadao

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Kunieda Takehisa

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Ishizuka Tadao

  Faculty of Life Sciences, Kumamoto University

• Kunieda Takehisa

  Faculty of Pharmaceutical Sciences, Kumamoto University

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• Pratical Preparation of Chiral 4-Substituted 2-Oxazolidinones
• Synthetic Versatility of 2-Oxazolone Heterocycle for Stereo-controlled Construction of 2-Amino Alcohols
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