Short-to Mid-Term Effects of Ovariectomy on Bone Turnover, Bone Mass and Bone Strength in Rats(Pharmacology)
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概要
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To determine the short- to mid-term effects of ovariectomy on bone turnover, bone mass and bone strength in rats. SD rats aged 12 weeks were randomly divided into No-treatment, Sham and OVX groups. The rats were sacrificed for sample collection at week 0, week 4 and week 18 after surgical operation. Chemistries in serum and urine were measured by standard colorimetric methods and bone turnover markers were measured by ELISA kits. Bone mass and bone strength were determined using pQCT system and three-point bending tests, respectively. At week 4, OVX rats showed drastic increase in the level of urine Ca, P and DPD. At week 18, in OVX rats the levels of serum ALP, urine DPD and Ca were much higher and the level of serum Ca was much lower when comparing with Sham rats. Ovariectomy produced significant reduction in cancellous BMD, total BMD and SSI of proximal tibial metaphysis rapidly at week 4 and continuously at week 18 after surgical operation. However, no marked changes of bone mass and bone strength were found in the diaphysis of tibia and femur, respectively, The current study concluded that ovariectomy induced the uncoupling of bone turnover, and the proximal metaphysis of long bone was the sensitive site for the short- to mid-term effect of ovariectomy, demonstrated as the markers of bone mass and stress strain index.
- 2007-05-01
著者
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ZHANG Yan
School of Pharmacy, Shenyang Pharmaceutical University
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LAI Wan-Ping
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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LEUNG Ping-Chung
Department of Orthopaedics and Traumatology, the Chinese University of Hong Kong
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WU Chun-Fu
School of Pharmacy, Shenyang Pharmaceutical University
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WONG Man-Sau
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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Leung Ping-chung
Department Of Orthopaedics And Traumatology The Chinese University Of Hong Kong
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ZHANG Yan
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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Wu Chun-fu
中華人民共和国
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Wu Chun-fu
School Of Pharmacy Shenyang Pharmaceutical University
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Wong Man-sau
Central Lab. Inst. Of Molecular Technol. For Drug Discovery And Synthesis Dep. Of Applied Biology An
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Wong Man-sau
Central Laboratory Institute Of Molecular Technology For Drug Discovery And Synthesis Department Of
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Lai Wan-ping
State Key Laboratory Of Chinese Medicine And Molecular Pharmacology:department Of Applied Biology An
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ZHANG Yan
School of Materials Science and Engineering, Beijing Institute of Fashion Technology
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