Involvement of Promyelocytic Leukemia Protein in the Ethanol-induced Apoptosis in Mouse Embryo Fibroblasts

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概要

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• The promyelocytic leukemia (PML) gene is a tumor suppressor gene associated with cell apoptosis, cell proliferation, and senescence. However, the role of PML in the ethanol-induced apoptosis is not fully-known. In this study, using wild-type mouse embryo fibroblasts (MEF) and PML null MEF cells, we found that (1) ethanol (100 mM and 200 mM) could obviously induce apoptosis of wild-type MEF cells, whereas, in PML null MEF cells, the pro-apoptotic function of ethanol was partially blocked; (2) the expression levels of phosphorylated p53 and two of its target genes, p21 and Bax, could be significantly up-regulated by ethanol (200 mM) in wild-type MEF cells in a time-dependent manner, but not in PML null MEF cells. These results indicate that PML plays an important role in ethanol-induced apoptosis, and p53-dependent apoptotic pathway may be involved in this process.

• 公益社団法人日本薬学会の論文
• 2008-07-01

著者

• Cui Wei

  中華人民共和国

• Cui Wei

  Department Of Cardiology The Second Hospital Of Hebei Medical University

• WANG Li-Hui

  Department of Pharmacology, College of Life Science and Biopharmaceutical of Shenyang Pharmaceutical

• Wang Li-hui

  中華人民共和国

• Wu Chun-fu

  Department Of Pharmacology Shenyang Pharmaceutical University College Of Life Science And Biopharmac

• Wang Li-hui

  Department Of Cardiology The First Hospital Of Beijing Medical University P.r.china

• YANG Jing-Yu

  Department of Pharmacology, Shenyang Pharmaceutical University College of Life Science and Biopharma

• SHIN Young

  Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University Coll

• Yang Jing-yu

  Department Of Pharmacology Shenyang Pharmaceutical University College Of Life Science And Biopharmac

• Shin Young

  Research Institute Of Pharmaceutical Science Department Of Pharmacy Seoul National University Colleg

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