New Phenanthrenes and Stilbenes from Dendrobium loddigesii

スポンサーリンク

概要

• 論文の詳細を見る

• New phenanthrenes, loddigesiinols A (1) and B (7), and stilbenes, loddigesiinols C (8) and D (9), were isolated from 80% ethanol extract of Dendrobium loddigesii ROLFE (Orcharedceae) along with known compounds, including five phenanthrenes, three stilbenes, two lignans, and three sterols. Their structures were determined by spectroscopic studies. These compounds were evaluated for their inhibitory activities against nitric oxide (NO) production and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Phenanthrenes (1—3, 7) and dihydrophenanthrenes (4—6) showed significant inhibitory activity against NO production. In particular, 2 showed stronger inhibitory activity against NO production than 5 and 6. This suggested that this phenanthrene is a stronger inhibitor of NO production than dihydrophenanthrene. The new phenanthrenes, loddigesiinols A (1) and B (7), significantly inhibited NO production with IC50 values of 2.6 and 10.9 μM, respectively. One new dihydrostilbene, loddigesiinol D (9), showed weak inhibitory activity against NO production with an IC50 value of 69.7 μM, but the other new dihydrostilbene, loddigesiinol C (8), did not show this activity at 100 μM.

著者

• Wang Nai-li

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Yao Xin-sheng

  Institute Of Molecular Immunology Southern Medical University

• Matsuzaki Keiichi

  Research Center Of Biological Function The Kitasato Institute School Of Pharmacevtical Sciences Kita

• Kitanaka Susumu

  Research Unit Of Pharmacognosy College Of Pharmacy Nihon University

• Ito Masanobu

  Research Unit of Pharmacognosy, School of Pharmacy, Nihon University

• Wang Jue

  Research Unit of Pharmacognosy, School of Pharmacy, Nihon University

• Daikonya Akihiro

  Research Unit of Pharmacognosy, School of Pharmacy, Nihon University

• Kitanaka Susumu

  Research Unit of Pharmacognosy, School of Pharmacy, Nihon University

• Wang Nai-Li

  Department of Natural Products Chemistry, Shenyang Pharmaceutical University

関連論文

• Four New Cycloartane Glycosides from Thalictrum fortunei
• New Phenanthrenes and Stilbenes from Dendrobium loddigesii
• The Neuritogenesis Inducer Lactacystin Arrests Cell Cycle at Both Go/G1 and G2 Phases in Neuro 2a Cells
• Direct Production of 5-Oxo Derivatives of Avermectins by a Recombinant Strain of Streptomyces avermitilis
• Dechlorogeodin and Its New Dihydro Derivatives, Fungal Metabolites with Herbicidal Activity
• Coumarins from Campylotropis hirtella (FRANCH.) SCHINDL. and Their Inhibitory Activity on Prostate Specific Antigen Secreted from LNCaP Cells
• Analysis of the CDR3 length of TCR αβ T cells in the peripheral blood of patients with chronic hepatitis B
• Fortuneanosides G-L, Dibenzofuran Glycosides from the Fruit of Pyracantha fortuneana
• Synthesis and Inhibitory Activities of Isochromophilone Analogues against gp120-CD4 Binding
• Securinega Alkaloids from Flueggea leucopyra
• Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
• The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
• Anti-Stress Effect of Oolong Tea in Women Loaded with Vigil
• Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide(Pharmacology)
• Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, and Physico-chemical Properties and Biological Activities
• Production of a New Methylated 6, 8a-Seco-6, 8a-deoxy Derivative of the Avermectins by a Transformant Strain of Streptomyces avermitilis
• Production of 6, 8a-Seco-6, 8a-deoxy Derivatives of Avermectins by a Mutant Strain of Streptomyces avermitilis
• Structure-activity Relationships of Lactacystin, the First Non-protein Neurotrophic Factor
• Diterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of Xenopus (2)
• New Brominated and Halogen-less Derivatives and Structure-activity Relationship of Azaphilones Inhibiting gp120-CD4 Binding
• Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. II. Structure Elucidation of Chloropeptin I
• Isochromophilones I and II, Novel Inhibitors against gp120-CD4 Binding Produced by Penicillium multicolor FO-2338 II.Structure Elucidation
• Isochromophilones I and II, Novel Inhibitors against gp120-CD4 Binding Produced by Penicillium multicolor FO-2338 I.Screening, Taxonomy, Fermentation, Isolation and Biological Activity
• The Anti-stress Effects of Guangdong Herbal Tea on Immunocompromise in Mice Loaded with Restraint Stress
• Effect of Cocoa Tea (Camellia ptilophylla) Co-Administrated with Green Tea on Ambulatory Behaviors
• Macrostemonoside A Promotes Visfatin Expression in 3T3-L1 Cells(Highlighted paper selected by Editor-in-chief,Molecular and Cell Biology)
• New benzophenone and quercetin galloyl glycosides from Psidium guajava L.
• Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. III. The Third Year (2010-2011)
• A Spectral Study of the Black Hole Candidate XTE J1752-223 in the High/Soft State with MAXI, Suzaku, and Swift
• FIBRE-Pac : FMOS Image-Based Reduction Package
• Peculiarly Narrow SED of GRB 090926B with MAXI and Fermi/GBM
• Revisit of Local X-Ray Luminosity Function of Active Galactic Nuclei with the MAXI Extragalactic Survey
• MAXI GSC Monitoring of the Crab Nebula and Pulsar during the GeV Gamma-Ray Flare in 2010 September
• Long-Term Monitoring of the Black Hole Binary GX 339-4 in the High/Soft State during the 2010 Outburst with MAXI/GSC
• Multi-Wavelength Photometric and Polarimetric Observations of the Outburst of 3C 454.3 in 2009 December
• NIR Spectroscopy of Star-Forming Galaxies at z-1.4 with Subaru/FMOS : The Mass-Metallicity Relation
• Data-Oriented Diagnostics of Pileup Effects on the Suzaku XIS
• Suzaku Studies of Wide-Band Spectral Variability of the Bright Type I Seyfert Galaxy Markarian 509
• Suzaku and XMM-Newton Observations of the Fornax Cluster : Temperature and Metallicity Distribution
• An X-Ray Spectroscopic Study of the Hot Interstellar Medium toward the Galactic Bulge
• A Suzaku Study of Ejecta Structure and Origin of Hard X-Ray Emission in the Supernova Remnant G 156.2+5.7
• Properties of the Intracluster Medium of Abell 3667 Observed with Suzaku XIS
• Suzaku Observations of Iron K-Lines from the Intracluster Medium of the Coma Cluster
• Suzaku Observations of Metal Distributions in the Intracluster Medium of the Centaurus Cluster
• Suzaku Metal Abundance Patterns in the Outflow Region of M 82 and the Importance of Charge Exchange
• Suzaku Detection of Diffuse Hard X-Ray Emission outside Vela X
• The Suzaku Discovery of A Hard Power-Law Component in the Spectra of Short Bursts from SGR 0501+4516
• ついにとらえたガンマ線バーストの偏光(最近の研究から)
• 今年で宇宙X線も発見50年(宇宙線100周年)
• 27aGJ-3 ガンマ線バースト偏光検出器(GAP)による系統的な偏光解析(27aGJ X線・γ線,宇宙線・宇宙物理領域)
• 26pGJ-13 衛星搭載軟ガンマ線検出器用高精細金属コリメータの性能評価(26pGJ X線(ASTRO-Hなど),宇宙線・宇宙物理領域)
• 26pGJ-12 硬X線撮像検出器HXIに向けたアクティブシールド機能の検証実験(26pGJ X線(ASTRO-Hなど),宇宙線・宇宙物理領域)
• 26pGJ-9 X線衛星ASTRO-H搭載軟ガンマ線検出器システムの熱設計と検証(26pGJ X線(ASTRO-Hなど),宇宙線・宇宙物理領域)
• 14aSP-9 Astro-H衛星搭載軟ガンマ線検出器の開発(14aSP X線,宇宙線・宇宙物理領域)
• 14pSP-4 衛星搭載を目指したガンマ線バースト偏光度検出器の基礎開発(14pSP ガンマ線,宇宙線・宇宙物理領域)
• 14aSP-2 「すざく」で解明された弱磁場中性子星Aql X-1における降着流の幾何(14aSP X線,宇宙線・宇宙物理領域)
• 14pSP-5 IKAROS搭載ガンマ線バースト偏光検出器(GAP)による高偏光度プロンプト放射の検出(14pSP ガンマ線,宇宙線・宇宙物理領域)
• 27pBE-9 衛星搭載軟ガンマ線検出器用高精細金属コリメータの性能評価(2)(27pBE X線・γ線,宇宙線・宇宙物理領域)
• 27pBE-5 Astro-H衛星搭載軟ガンマ線検出器の開発(2012年度後半)(27pBE X線・γ線,宇宙線・宇宙物理領域)
• 28pBE-1 小型衛星搭載用GRB偏光度検出器の開発(28pBE X線・γ線,宇宙線・宇宙物理領域)
• 27pBE-6 次期X線衛星ASTRO-H搭載BGOシールド部の信号処理ファームウェアの動作検証(27pBE X線・γ線,宇宙線・宇宙物理領域)

もっと見る 閉じる

スポンサーリンク