Huanglian-Jie-Du-Tang Extract Protects against Chronic Brain Injury after Focal Cerebral Ischemia via Hypoxia-Inducible-Factor-1α-Regulated Vascular Endothelial Growth Factor Signaling in Mice
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概要
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Huanglian-Jie-Du-Tang (HJDT) is a traditional Chinese herbal formula which is widely used clinically. In this study, we investigated the effects of an aqueous (HJDTaq) and an ethanolic (HJDTet) extract of HJDT on chronic brain injury after focal cerebral ischemia in mice. The ischemia was induced by occlusion of the right middle cerebral artery for 30 min. HJDTaq (4 g/kg) and HJDTet (200, 400, 800 mg/kg) were orally administered for 21 d from day 7 before ischemia to day 14 after ischemia. The survival rate decreased to less than 50% at 35 d after ischemia. HJDTet at 400 mg/kg increased the survival rate. HJDTaq (4 g/kg) and HJDTet (400, 800 mg/kg) significantly attenuated the neurological dysfunction, brain atrophy and infarct volume after ischemia. There were few cells positive for CD31, hypoxia-inducible-factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and Flk-1 in the sham control. After ischemia, the number increased. HJDTaq (4 g/kg) and HJDTet (400 or 800 mg/kg) further increased the numbers of CD31, HIF-1α, VEGF and Flk-1-positive cells in the ischemic hemisphere. We conclude that HJDTaq and HJDTet have neuroprotective effects on chronic brain injury after focal cerebral ischemia and lead to accelerated angiogenesis by HIF-1α-regulated VEGF signaling.
- 公益社団法人 日本薬学会の論文
著者
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Wang Jue
Department Of Pharmacognosy College Of Pharmacy Nihon University
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Rao Yan
Department Of Nuclear Engineering Faculty Of Engineering Kyushu Univ.
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Zhang Qi
Department Of Cardiology Rui Jin Hospital Shanghai Jiao Tong University School Of Medicine
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Ye Yilu
Department of Pharmacology, Zhejiang Medical College
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Huang Chunyan
Department of Pharmacology, Zhejiang Medical College
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Jiang Lili
Department of Pharmacology, Zhejiang Medical College
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Shen Xiangdi
Department of Pharmacology, Zhejiang Medical College
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Zhu Shanyong
Department of Pharmacology, Zhejiang Medical College
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Rao Yan
Department of Pharmacology, Zhejiang Medical College
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WANG Jue
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Wang Jue
Department of Pharmacology, Zhejiang Medical College
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Zhang Qi
Department of Pharmacology, Zhejiang Medical College
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