Antidepressant Effect of Extracts from Ginkgo biloba Leaves in Behavioral Models(Medicinal Chemistry)
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概要
- 論文の詳細を見る
Extracts of Ginkgo biloba (EGB) are a complex product prepared from green leaves of the Ginkgo biloba tree. In the present study, the antidepressant effect of EGB was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in mice. EGB significantly reduced immobility time in the FST at a dosage of 10 and 50mg/kg body weight after repeated oral treatment for 14d, although no change of motor dysfunction was observed with the same dosage in the open field test. These results indicate that EGB might possess an antidepressant activity. In addition, EGB markedly shortened immobility time in the TST after acute inter-peritoneal treatment at a dosage of 50 and 100mg/kg body weight. The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
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MINAMI Yuko
Department of Medical Oncology, Dana Farber Cancer Center Institute
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SAKAKIBARA Hiroyuki
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University
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Minami Yuko
Department Of Molecular Pathology Institute Of Biomolecular And Integrated Medical Sciences Graduate
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Minami Yuko
Department Of Epidemiology Miyagi Cancer Center
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Minami Yuko
Departments Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Sch
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ISHIDA Kaori
Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate Scho
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GRUNDMANN Oliver
Department of Pharmaceutics, University of Florida
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NAKAJIMA Jun-ichiro
Tokiwa Phytochemical Co., Ltd.
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SEO Shujiro
Tokiwa Phytochemical Co., Ltd.
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BUTTERWECK Veronika
Department of Pharmaceutics, University of Florida
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SAITO Satomi
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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KAWAI Yoshichika
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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NAKAYA Yutaka
Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate Scho
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TERAO Junji
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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Terao Junji
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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Seo Shujiro
常盤薬品工業
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Seo Shujiro
Tokiwa Phytochemical Co.
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Saito Satomi
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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Ishida Kaori
Nutrition And Metabolism Inst. Of Health Biosciences The Univ. Of Tokushima Graduate School
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Ishida Kaori
Nutrition And Metabolism Institute Of Health Biosciences The University Of Tokushima Graduate School
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Nakaya Yutaka
徳島大学 ヘルスバイオサイエンス研究部臓器病態治療学
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Grundmann Oliver
Department Of Pharmaceutics University Of Florida
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Kanematsu Yasuhisa
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Nakajima Jun-ichiro
Tokiwa Phytochemical
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Butterweck Veronika
Department Of Pharmaceutics University Of Florida
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Kawai Yoshichika
Department Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Kawai Yoshichika
Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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Nakaya Yutaka
Nutrition And Metabolism Institute Of Health Biosciences The University Of Tokushima Graduate School
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Terao Junji
Dep. Of Food Sci. Inst. Of Health Bioscience The Univ. Of Tokushima Graduate School Jpn
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Sakakibara Hiroyuki
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Sakakibara Hiroyuki
Departments Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Sch
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Terao Junji
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Saito Satomi
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Butterweck Veronika
Department Of Pharmaceutics College Of Pharmacy University Of Florida
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Kawai Yoshichika
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Terao Junii
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School
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SAKAKIBARA Hiroyuki
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University
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