Antidepressant-Like Effect of Onion (Allium cepa L.) Powder in a Rat Behavioral Model of Depression
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概要
- 論文の詳細を見る
The present study evaluated the antidepressant-like effect of the quercetin-rich vegetable, onion, by using the rat behavioral model of depression, the forced swimming test (FST). Daily administration of onion powder at a dosage of 50 mg/kg of body weight/day for 14 days significantly reduced the immobility time in FST without changing the motor dysfunction, indicating that the daily consumption of onion exerted antidepressant-like activity. The plasma corticosterone level was elevated after an FST trial, and pretreatment with onion powder did not modulate this elevation. Although the FST trial tended to increase the dopaminergic activity in the rat hypothalamus, the administration of onion powder (50 mg/kg) suppressed the increase in the turnover of this neurotransmitter. However, the same prevention was also observed with a higher dosage of onion, in which no significant antidepressant effect was apparent. The results of the present study suggest that onion exerted antidepressant-like activity in a behavioral model that acted independently of the hypothalamic-pituitary-adrenal axis.
- 2008-01-23
著者
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Terao Junji
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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Kanematsu Yasuhisa
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Kawai Yoshichika
Department Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Kawai Yoshichika
Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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Terao Junji
Dep. Of Food Sci. Inst. Of Health Bioscience The Univ. Of Tokushima Graduate School Jpn
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Sakakibara Hiroyuki
Department Of Biofunctional Chemistry Faculty Of Agriculture Kobe University
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Sakakibara Hiroyuki
Departments Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Sch
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Terao Junji
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Yoshino Saki
Departments Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Sch
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Kawai Yoshichika
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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SAKAKIBARA Hiroyuki
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University
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