Different Profiles of Quercetin Metabolites in Rat Plasma : Comparison of Two Administration Methods
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概要
- 論文の詳細を見る
The bioavailability of polyphenols in human and rodents has been discussed regarding their biological activity. We found different metabolite profiles of quercetin in rat plasma between two administration procedures. A single intragastric administration (50 mg/kg) resulted in the appearance of a variety of metabolites in the plasma, whereas only a major fraction was detected by free access (1% quercetin). The methylated/non-methylated metabolites ratio was much higher in the free access group. Mass spectrometric analyses showed that the fraction from free access contained highly conjugated quercetin metabolites such as sulfo-glucuronides of quercetin and methylquercetin. The metabolite profile of human plasma after an intake of onion was similar to that with intragastric administration in rats. In vitro oxidation of human low-density lipoprotein showed that methylation of the catechol moiety of quercetin significantly attenuated the antioxidative activity. These results might provide information about the bioavailability of quercetin when conducting animal experiments.
- 社団法人 日本農芸化学会の論文
- 2009-03-23
著者
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SAITO Satomi
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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KAWAI Yoshichika
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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TERAO Junji
Departments of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate S
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Terao Junji
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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Saito Satomi
Dep. Of Food Sci. Graduate School Of Nutrition And Biosciences The Univ. Of Tokushima
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Kanematsu Yasuhisa
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Kawai Yoshichika
Department Of Food Science Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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MUROTA Kaeko
Department of Nutorition, School of Medicine, The University of Tokushima
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Kawai Yoshichika
Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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NISHIKAWA Tomomi
Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushim
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ISHISAKA Akari
Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushim
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Murota Kaeko
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Terao Junji
Dep. Of Food Sci. Inst. Of Health Bioscience The Univ. Of Tokushima Graduate School Jpn
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Terao Junji
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Saito Satomi
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Murota Kaeko
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Ishisaka Akari
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Nishikawa Tomomi
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Kawai Yoshichika
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Nishikawa Tomomi
Department of Chemistry, Osaka Kyoiku University
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