Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery:Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling
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概要
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Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations. A major mechanism mediating adaptive responses to reduced oxygen availability is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1). Impairment of HIF-1–dependent inflammatory responses in T cells causes an augmented vascular remodeling induced by arterial injury, which is shown as prominent neointimal hyperplasia and increase in infiltration of inflammatory cells at the adventitia in mice lacking Hif-1α specifically in T cells. Studies to clarify the mechanism of augmented vascular remodeling in the mutant mice have shown enhanced production of cytokines in activated T cells and augmented antibody production in response to a T-dependent antigen in the mutant mice. This minireview shows that HIF-1α in T cells plays a crucial role in vascular inflammation and remodeling in response to cuff injury as a negative regulator of the T cell–mediated immune response and suggests potential new therapeutic strategies that target HIF-1α.
- 社団法人 日本薬理学会の論文
著者
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Tomita Shuhei
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Tomita Shuhei
徳島大学 ヘルスバイオサイエンス研究部薬理学
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Tomita Shuhei
徳島大学 ヘルスバイオサイエンス研究部薬理学分野
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Tomita Shuhei
Division Of Experimental Immunology Institute For Genome Research The University Of Tokushima Gradua
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Fukuhara Yayoi
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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Tamaki Toshiaki
Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school
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ISHIZAWA Keisuke
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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TSUCHIYA Koichiro
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences
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IMAMURA Yuko
Department of Dermatology, School of Medicine, Iwate Medical University
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Imamura Yuko
Department Of Dermatology Iwate Medical University School Of Medicine
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Ikeda Yasumasa
Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of He
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Ikeda Yasumasa
Department Of Cardiology Tokushima Prefectural Central Hospital
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Kihira Yoshitaka
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Ishihara Manabu
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Sugihara Takashi
Division Of Cardiovascular Medicine Tokushima University Hospital
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Ishizawa Keisuke
Department Of Neurology Neurological Institute Tokyo Women's Medical College
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Tsuchiya Koichiro
Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad
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Kanematsu Yasuhisa
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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Soeki Takeshi
Department Of Cardiovascular Medicine The University Of Tokushima
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Fukuhara Yayoi
Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S
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Imanishi Masaki
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate Sc
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Kawai Yoshichika
Dep. Of Pharmacology The Inst. Of Health Bioscience The Univ. Of Tokushima
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Kihira Yoshitaka
Department Of Neural And Pain Sciences Program In Neuroscience University Of Maryland:faculty Of Pha
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Ishizawa Keisuke
Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu
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Fukuhara Yayoi
Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho
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