Regional Hemodynamic Effects of Betaxolol, a New Selective .BETA.1-Blocker, and Atenolol in Conscious Spontaneously Hypertensive Rats.
スポンサーリンク
概要
- 論文の詳細を見る
Betaxolol is a new β-blocker that has been reported to have β<SUB>1</SUB>-selectivity, and it is devoid of both membrane stabilizing action and intrinsic sympathomimetic action. The effects of betaxolol on systemic and regional hemodynamics were examined in conscious spontaneously hypertensive rats (SHR) by a microsphere method and compared with the effects of atenolol. A single oral administration of betaxolol at 1 and 10 mg/kg decreased the mean arterial pressure in a dose-dependent manner. At the same doses, atenolol also showed a similar but weak hypotensive effect. Both of these drugs at the high dose decreased cardiac output and heart rate and at the low dose, did not. Total peripheral resistance decreased by only betaxolol at the low dose. Betaxolol showed a tendency to normalize the hemodynamic abnormalities which were observed in the kidney, spleen and gastrointestinal tract of SHR, while atenolol did not. It should be noted that betaxolol increased the flow rate in the kidney, which may be explained by its direct vasodilatory action on renal blood vessels. In conclusion, betaxolol showed an antihypertensive action at the doses of 1 and 10 mg/kg, exhibited the characteristics of a β<SUB>1</SUB>-blocker and produced preferable effects on regional hemodynamics in SHR.
- 公益社団法人 日本薬理学会の論文
著者
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FUJISAWA Yoshihide
Research Equipment Center, Kagawa Medical University
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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Nishiyama Akira
Department Of Pharmacology Faculty Of Medicine Kagawa University
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Kiyomoto Hideyasu
Department Of Cardio Renal And Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Shoji Tetsuo
Department Of Metabolism Endocrinology And Molecular Medicine Graduate School Of Medicine
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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AKI Yasuharu
Department of Pharmacology, Kagawa Medical School
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Kiyomoto Hideyasu
Department of Pharmacology, Kagawa Medical School
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IWAO Hiroshi
Department of Pharmacology, Kagawa Medical School
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Horiuchi Kunisuke
Department of Pharmacology, Kagawa Medical School
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He Hong
Department of Pharmacology, Kagawa Medical School
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SHOJI Tetsuo
Department of Pharmacology, Kagawa Medical School
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Fujisawa Yoshihide
Research Equipment Center, Kagawa Medical School
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