Drug Discovery for Overcoming Chronic Kidney Disease (CKD) : Pharmacological Effects of Mineralocorticoid-Receptor Blockers

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概要

• 論文の詳細を見る

• There is increasing evidence demonstrating that the renoprotective effects of mineralocorticoid receptor (MR) blockade are independent of the effects exerted by renin-angiotensin inhibitors. MR is expressed not only in tubular cells but also in other renal cells including glomerular mesangial cells, podocytes, and renal interstitial fibroblasts. Animal experiments have shown that MR blockers prevent aldosterone-induced proteinuria, glomerular injury, and tubulointerstitial fibrosis. In vitro studies have also demonstrated that MR blockers inhibit aldosterone-induced renal cell damage. Recent clinical studies have shown that treatment with MR blockers attenuates the development of proteinuria in patients with chronic kidney disease (CKD) and hypertension, independent of changes in blood pressure. In some cases, MR blockers elicit potent renoprotective effects in conditions where aldosterone levels are not elevated. These data suggest that treatment with MR blockers may possibly present an effective therapeutic strategy for patients with CKD.

• 社団法人 日本薬理学会の論文
• 2009-01-20

著者

• NISHIYAMA Akira

  Department of Pharmacology, Kagawa Medical University

• HITOMI Hirofumi

  Department of Pharmacology, Kagawa University Medical School

• KIYOMOTO Hideyasu

  Department of Cardiorenal and Cerebrovascular Internal Medicine

• Nishiyama Akira

  Department Of Pharmacology Kagawa University Medical School

• Nishiyama Akira

  Advanced Lsi Technology Laboratory Corporate Research & Development Center Toshiba Corporation

• Kiyomoto Hideyasu

  Department Of Integrated Medicine Kagawa University

• Kiyomoto Hideyasu

  Second Department Of Internal Medicine Kagawa Medical University

• Nishiyama Akira

  Department Of Pharmacology Faculty Of Medicine Kagawa University

• RAHMAN Asadur

  Department of Pharmacology, Bangladesh Agricultural University

• Kiyomoto Hideyasu

  Department Of Cardio Renal And Cerebrovascular Medicine Kagawa University Faculty Of Medicine

• Kiyomoto Hideyasu

  Department Of Physiology Hypertension And Renal Center Of Excellence Tulane University Health Scienc

• Rahman Asadur

  Department Of Pharmacology Bangladesh Agricultural University

• Nishiyama Akira

  Faculty Of Medicine Department Of Pharmacology Kagawa University

• Hitomi Hirofumi

  Department Of Pharmacology Faculty Of Medicine Kagawa University

• Kiyomoto Hideyasu

  香川大学 医学部循環器･腎臓･脳卒中内科

• Kobori Hiroyuki

  Department Of Physiology Hypertension And Renal Center Of Excellence Tulane University Health Scienc

• Kiyomoto Hideyasu

  Department Of Pharmacology Faculty Of Medicine Kagawa University

• Hitomi Hirofumi

  Department Of Pharmacology Kagawa University Medical School

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