Effect of L-NG-Nitro-Arginine, Inhibitor of Nitric Oxide Synthesis, on Autoregulation of Renal Blood Flow in Dogs.
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概要
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The present experiments were designed to evaluate the importance of nitric oxide in the regulation of renal hemodynamics and the autoregulation of renal blood flow (RBF) in anesthetized dogs. RBF was measured by an electromagnetic flowmeter, and renal arterial pressure (RAP) was varied by an adjustable aortic clamp. The RAP-RBF relations were examined during the intrarenal infusion of saline or agents. The intrarenal infusion of L-<I>N<SUP>G</SUP></I>-nitro-arginine (L-NNA, 40 μg/kg·min) at normal RAP decreased RBF and urine flow (UF), while the infusion of L-arginine·HCI (1 mg/kg.min) increased RBF and UF. Both agents did not affect the glomerular filtration rate and mean arterial pressure. The autoregulation of RBF was impaired during the L-NNA infusion. The L-arginine infusion did not affect autoregulatory efficiency. When L-NNA (40 μg/kg·min) and L-arginine were infused simultaneously into the renal artery, the autoregulation of RBF was maintained. However, a higher dose of L-NNA (200 μg/kg·min) impaired the autoregulation of RBF. These results suggest that the basal production and/or the release of nitric oxide contributes to the regulation of renal hemodynamics and urine formation. During the reduction of RAP, nitric oxide may play an important role in the autoregulation of RBF.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuo Hirohide
Second Department Of Internal Medicine Kagawa Medical School
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Kiyomoto Hideyasu
Second Department Of Internal Medicine Kagawa Medical University
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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AKI Yasuharu
Department of Pharmacology, Kagawa Medical School
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Kiyomoto Hideyasu
Second Department of Internal Medicine, Kagawa Medical School
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Hong He
Department of Pharmacology, Kagawa Medical School
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