Effects of NG-Nitro-L-Arginine on Isolated Rabbit Afferent Arterioles.
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概要
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We examined the effects of <I>N<SUP>G</SUP></I>-nitro-L-arginine (L-NNA) on isolated rabbit afferent arterioles to confirm that nitric oxide is released at the resistance vessel level in the kidney. We microdissected the superficial afferent arterioles from the kidneys of New Zealand White rabbits. Each afferent arteriole was cannulated with a micropipette system, and the intraluminal pressure was set at 80 mmHg. By our methods, we found that norepinephrine (NE) decreased the lumen diameter of the afferent arterioles in a dose-dependent manner, and acetylcholine increased the lumen diameter of NE-constricted afferent arterioles. L-NNA (10<SUP>-4</SUP> M) gradually decreased the lumen diameter of afferent arterioles from 21.5±0.9 to 18.6±0.9 μm in 20 min, but <I>N<SUP>G</SUP></I>-nitro-D-arginine (10<SUP>-4</SUP> M) did not affect them (from 21.8±1.3 to 21.8±1.5 μm). L-Arginine (10<SUP>-4</SUP> M) restored the lumen diameter of L-NNA-contracted afferent arterioles to the control levels. These findings indicate that the isolated afferent arteriole has the ability to release or to synthesize and release nitric oxide under basal conditions and that this basal release of nitric oxide plays an important role in the basal tone of the afferent arteriole.
- 公益社団法人 日本薬理学会の論文
著者
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Kimura Shoji
Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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HASUI Kouichi
Departments of Kagawa Medical School Neurological Surgery Pharmacology
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AKI Yasuharu
Department of Pharmacology, Kagawa Medical School
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HASUI Kouichi
Department of Pharmacology, Kagawa Medical School
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