Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.
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概要
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We studied the expression of angiotensinogen and renin genes in rats treated with 3, 3', 5-triiodo-L-thyronine (T<SUB>3</SUB>) at doses of 0.1 and 1 mg/kg of body weight. Liver angiotensinogen mRNA increased by 2 to 3 times 8 to 12 hours after T<SUB>3</SUB>-treatment. This increase was dose-related. Plasma angiotensinogen concentration (PAC) increased 12 hours after T<SUB>3</SUB>-treatment. Brain and renal angiotensinogen mRNA levels and the renal renin mRNA level remained the same throughout the experimental periods. These results suggest that the thyroid hormone initially increases angiotensinogen mRNA and leads to an increase in the production of angiotensinogen in the liver followed by an elevation of PAC.
- 公益社団法人 日本薬理学会の論文
著者
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Kimura Shoji
Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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Fukui Kiyoshi
Department Of Biochemistry National Cardiovascular Center Research Institute
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Tanaka Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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ABE Youichi
Departments of Pharmacology, Kagawa Medical School
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TANAKA Satoshi
Departments of Surgery, Kagawa Medical School
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