Ginsenoside Rb_1 Reduces Neurodegeneration in the Peri-infarct Area of a Thromboembolic Stroke Model in Non-human Primates
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概要
- 論文の詳細を見る
Ginsenoside Rb1 (GRb1), a major component of the traditional herb ginseng, has been reported to show a neuroprotective effect in a rodent ischemic model. The purpose of this study was to investigate effects of GRb1 on early and delayed brain injuries in a non-human primate thromboembolic stroke model. Thromboembolic stroke was induced by occlusion of the middle cerebral artery by injection of an autologous blood clot into the left internal carotid artery. GRb1 (300 μg/kg per day, i.v.) and vehicle were administered from 7 days before embolization to the day following embolization (total: 8 times). Neurological deficits were observed at 1, 6, and 24 h and at 2, 4, and 7 days after embolization. At 7 days after embolization, neuron damage in the peri-infarct area and core region were assessed by NeuN, TUNEL, and GFAP staining. GRb1 improved the skeletal muscle coordination score of the neurologic deficits (median: GRb1 vs vehicle = 10 vs 12, P<0.05). In the GRb1 group, positive neurons expressed by NeuN staining were noted in the ischemic peri-infarct area, and TUNEL- and GFAP-positive cells significantly decreased, when compared with vehicle. These results demonstrated that GRb1 ameliorated both early and delayed injuries in the thromboembolic stroke model in non-human primates.
- 2008-05-20
著者
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SAMUKAWA Keiichi
Department of Integrated Basic Medical Science, Division of Functional Histology, Ehime University S
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YOSHIKAWA Tetsuya
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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AKIYOSHI Yuki
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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SUSUMU Teruo
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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TOKADO Hiroshi
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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FUKUZAKI Koichiro
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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NAGATA Ryoichi
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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IWAO Hiroshi
Department of Pharmacology, Osaka City University School of Medicine
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KITO Go
Shin Nippon Biomedical Laboratories (SNBL), Ltd.
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Susumu Teruo
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Susumu Teruo
新日本科学
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Samukawa Keiichi
Department Of Pharmacology Osaka City University School Of Medicine
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Samukawa Keiichi
Department Of Integrated Basic Medical Science Division Of Functional Histology Ehime University Sch
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Kito Go
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Nagata Ryoichi
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Nagata Ryoichi
Shin Nippon Biomedical Laboratories Ltd.
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Akiyoshi Yuki
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Tokado Hiroshi
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Kito Go
新日本科学
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Iwao Hiroshi
Department Of Pharmacology Osaka City University School Of Medicine
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Iwao Hiroshi
Department Of Pharmacology Graduate School Of Medicine Osaka City University
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Yoshikawa Tetsuya
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Fukuzaki Koichiro
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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Kito Go
Shin Nippon Biomedical Laboratories (snbl) Ltd
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Fukuzaki Koichirou
Snbl Usa Ltd.
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Nagata Ryoichi
Toxicology Division Shin Nippon Biomedical Laboratories
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Nagata Ryoichi
Shin Nippon Biomedical Lab. Ltd.
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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