Observation of the Ischemic Cascade in Humans Using Contrast Echocardiography During Dobutamine Stress
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概要
- 論文の詳細を見る
Experimental studies have postulated the ischemic cascade and the present study was designed to elucidate whether it can be observed in the clinical setting. Fifty-three patients suspected of having coronary artery disease were studied. Myocardial perfusion abnormalities (MPA) and wall motion abnormalities (WMA) were assessed simultaneously by infusion of Levovist during dobutamine stress echocardiography. Time-intensity data of myocardial opacification were fitted for Y=A (l-e^<-βt>) from which the rate of increase (β) of intensity were derived both at rest and during stress. Wall motion was also given a score. Bright opacification was observed in 50 patients : 25 showed significant stenosis (>50%) in the left anterior descending artery (group II) on coronary angiography and 25 did not (group I). Significant differences were found in the β ratio (stress/rest) between the 2 groups at a low-dose (2.0±0.3 vs 1.5±0.5, p<0.05) and at a high-dose of dobutamine (2.7±1.0 vs 1.1±0.5, p< 0.001), whereas the wall motion score differed only at a high-dose. Of the 25 patients in group II, MPA preceded WMA in 12, both occurred at the same stage in 12, and neither MPA nor WMA was seen in 1. These data prove the ischemic cascade clinically, using contrast echocardiography, by demonstrating that MPA precede WMA during dobutamine stress in patients with coronary stenosis.
- 社団法人日本循環器学会の論文
- 2003-04-20
著者
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HOZUMI Takeshi
Departments of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine
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YOSHIYAMA Minoru
Departments of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine
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Yoshikawa Junichi
Department of Internal Medicine and Cardiology, Osaka City University School of Medicine
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Yamaguchi Junichi
Division Of Cardiology Saitama Prefecture Cardiovascular And Respiratory Center
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IWAO Hiroshi
Department of Pharmacology, Osaka City University School of Medicine
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Fukuda Shota
Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital
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Yoshiyama Minoru
Department Of Internal Medicine And Cardiology Graduate School Of Medicine Osaka City University
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Takeuchi Kazuhide
Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine
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Hozumi Takeshi
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Hozumi Takeshi
Department Of Internal Medicine And Cardiology
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Hozumi Takeshi
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Hozumi Takeshi
Division Of Cardiology Department Of Medicine Columbia University
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Takeuchi Kazuhide
大阪市立大学 医学部循環器病態内科学
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Takeuchi Kazuhide
大阪市立大学 医学研究科循環器病態内科学
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Takeuchi Kazuhide
The First Department Of Internal Medicine Osaka City University Medical School
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Fukuda Shota
Department Of Internal Medicine And Cardiology Osaka Ekisaikai Hospital
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Muro Takashi
Department Of Internal Medicine And Cardiology Oska City University Graduate School Of Medicine
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Hyodo Eiichi
Department of Cardiology, Higashisumiyoshi Morimoto Hospital
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Takeuchi Kazuhide
Department Of Internal Medicine And Cardiology Osaka City University Medical School
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Kadohira Tadayuki
千葉大学 医学研究院循環病態医科学
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Hyodo Eichi
Department Of Cardiology Higashisumiyoshi Morimoto Hospital
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Hyodo Eiichi
Higashisumiyoshimorimoto Hospital
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Yoshikawa Junichi
Department Of Cardiology Osaka City University Medical School
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Hyohdoh Eiichi
Department Of Cardiology Higashisumiyoshi Morimoto Hospital
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Watanebe Hiroyuki
Departments of Internal Medicine and Cardiology,Osaka City University School of Medicine
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Iwao Hiroshi
Department Of Pharmacology Graduate School Of Medicine Osaka City University
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Muro Takashi
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Hozumi Takeshi
The Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine
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Yoshiyama Minoru
Department Of Cardiology And Internal Medicine Medical School Osaka City University
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Muro Takashi
Department Of Cardiology And Internal Medicine Medical School Osaka City University
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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HOZUMI Takeshi
Department of Cardiology, Osaka City University
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YOSHIYAMA Minoru
Department Internal Medicine and Cardiology, Osaka City University School of Medicine
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