Assessment of Left Ventricular Systolic Function Using Contrast Two-Dimensional Echocardiography With a High-Frequency Transducer in the Awake Murine Model of Myocardial Infarction
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概要
- 論文の詳細を見る
The estimation of global left ventricular function using M-mode echocardiography has technical limitations in the murine model of myocardial infarction(MI), but the recent improvements in 2-dimensional(2-D)echocardiography using a high-frequency transducer provide more accessible images. Furthermore, intravenous injection of contrast agent has the additional benefit of enhancing the endocardial border in the murine heart. The present study was designed to evaluate the value of 2-D echocardiography with intravenous injection of contrast agent in the assessment of global systolic function of the murine heart with MI. Two-dimensional and M-mode echocardiography without and with intravenous injection of contrast agent(Optison, 0.1-0.15 ml)were performed in 76 awake mice 2 days before and 2 days after left coronary artery ligation. Fractional shortening(FS)was calculated from the end-diastolic and end-systolic diameters on M-mode echocardiography, and fractional area change(FAC)from the end-diastolic and end-systolic areas on 2-D echocardiography. Both FS and FAC were compared with the areas of hypoperfusion observed in the pathological samples. The use of contrast agent improved the number of hearts that could be evaluated by both the M-mode and 2-D method(M-mode: non-contrast 87% vs contrast 99%, p<0.01; 2-D: non-contrast 26% vs contrast 89%, p<0.001). FAC from the 2-D method correlated better with the region of hypoperfusion in the pathological samples than did FS from the M-mode method(FAC: r=0.84 vs FS: r=0.51). In conclusion, FAC obtained from 2-D contrast echocardiography is useful for noninvasive assessment of global systolic function in infarcted murine hearts and can be used to serially assess systolic function in various models of the murine heart.
- 社団法人日本循環器学会の論文
- 2001-10-20
著者
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HOZUMI Takeshi
Departments of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine
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Hozumi Takeshi
Department Of Internal Medicine And Cardiology
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Hozumi Takeshi
Departments Of Medicine Columbia University
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Homma Shunichi
Department of Medicine, Columbia University
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Burkhoff Daniel
Departments Of Medicine Columbia University
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Shimizu Juichiro
Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine and Dentistr
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Smith Craig
Departments Of Surgery Columbia University
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Homma Shunichi
Department Of Medicine Columbia University
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Homma Shunichi
Departments Of Medicine Columbia University
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SUEHIRO Kotaro
Department of Cardiovascular Surgery, Sakakibara Hospital Cardiovasculary Center
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Suehiro Kotaro
Department Of Cardiovascular Surgery Cardiovascular Center Sakakibara Hospital
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Suehiro Kotaro
Departments Of Surgery Columbia University
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Takuma Shin
Departments of Medicine, Columbia University
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Yano Hideaki
Departments of Medicine, Columbia University
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Cardinale Carol
Departments of Medicine, Columbia University
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DiTullio Marco
Departments of Medicine, Columbia University
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Wang Jie
Departments of Medicine, Columbia University
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Takuma Shin
Departments Of Medicine Columbia University
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Yano Hideaki
Departments Of Medicine Columbia University
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Ditullio Marco
Departments Of Medicine Columbia University
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Cardinale Carol
Departments Of Medicine Columbia University
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Shimizu Juichiro
Departments Of Medicine Columbia University
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Wang Jie
Department Of Chemistry & Nasa Center For High Performance Polymers And Composites Clark Atlanta
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Wang Jie
Department Of Applied Chemistry Faculty Of Engineering The University Of Tokyo
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HOZUMI Takeshi
Department of Cardiology, Osaka City University
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