Dominant Negative c-Jun Inhibits Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells
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概要
- 論文の詳細を見る
The mitogen–activated protein (MAP) kinase pathways has been shown to be necessary for mitogen-stimulated proliferation, but its role in cell migration has not been fully understood. In this study, we investigated the possible contribution of signaling pathways through c-Jun in platelet-derived growth factor (PDGF)-BB directed cell migration in rat aortic vascular smooth muscle cells (VSMCs) infected with a recombinant adenovirus containing the dominant-negative c-Jun (Ad-DN-c-Jun). DN-c-Jun protein was expressed dose-dependently in VSMCs infected with Ad-DN-c-Jun. Expression of DN-c-Jun significantly inhibited VSMC migration induced by PDGF-BB. Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs.
- 社団法人 日本薬理学会の論文
- 2003-02-01
著者
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HIRAI Midori
Department of Clinical Pharmacy, Kobe Pharmaceutical University
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IWAO Hiroshi
Department of Pharmacology, Osaka City University School of Medicine
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YAMAMORI Motohiro
Department of Hospital Pharmacy, Kobe University School of Medicine
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Iwao H
Departments Of Kagawa Medical School Neurological Surgery Pharmacology
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KIM Shokei
Department of Pharmacology, Osaka City Unitersity Medical School
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Kim Shokei
the Department of Pharmacology, Osaka City University Medical School
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Hirai Midori
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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YAGI Keiko
Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health
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Katsuma Susumu
Department Of Genomic Drug Discovery Science Kyoto University Graduate School Of Pharmaceutical Scie
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Yagi Keiko
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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Hirai Midori
Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric
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Kim S
大阪市立大学 薬理
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Yamamori Motohiro
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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IOROI Takeshi
Department of Clinical Pharmacy, Kobe Pharmaceutical University
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ZHAN Yumei
Department of Pharmacology, Osaka City University Medical School
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ZHAN Yumei
the Department of Pharmacology, Osaka City University Medical School
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Iwao Hiroshi
Department Of Pharmacology Graduate School Of Medicine Osaka City University
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Ioroi Takeshi
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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Zhan Yumei
Department Of Pharmacology Osaka City University Medical School
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Kim Shokei
Department Of Pharmacolgy Osaka City Unversity Medical School
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Iwao H
Osaka City Univ. Medical School Osaka Jpn
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Kim Shokei
Department Of Internal Medicine And Cardiology Osaka City University Medical School
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