EFFECTS OF PROSTAGLANDIN I_2 AND E_2 ON RENAL HEMODYNAMICS AND FUNCTION AND RENIN RELEASE

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The effects of PGI_2 and PGE_2 , given in the same doses were compared as to renal hemodynamics and functions and renin release. The same experimental conditions were used for both compounds and experiments were carried out in pentobarbital anesthetized dogs. Adrenergic influences were excluded by renal denervation. Given intrarenally at doses of 0.1μg/min and 1μg/min, PGE_2 caused significant increase in RBF, UF and U_<Na>V, but had no effect on BP and GFR. Intrarenal infusion of PGI_2 at a rate of 1μg/min resulted in a significant increase of RBF and in a marked fall of BP. but only little change in GFR, UF and U_<Na>V. With a dose of 0.1 μg/min, the parameters remained the same. Intravenous infusion of PGI_2 (1μg/min) caused a significant fall in BP with no change in the other parameters. Both PGI_2 and PGE_2 had a similar effect on intrarenal hemodynamics, i.e., caused a progressively greater proportional vasodilation from superficial to deep cortex. Given intrarenally in a dose of 1μg/min, PGI_2 and PGE_2 increased renin release. But with a dose of 0.1μg/min and 1μg/min, i.v., renin secretion was not influenced. The effect of PGI_2 on systemic blood pressure was more potent than that of PGE_2 , however, with regard to renal vasodilating action and tubular effects, PGE_2 was the more potent. Present data indicate that PGI_2 and PGE_2 stimulate renin secretion through a direct action on the juxtaglomerular cells.
社団法人日本循環器学会の論文
1980-12-20

EFFECTS OF PROSTAGLANDIN I_2 AND E_2 ON RENAL HEMODYNAMICS AND FUNCTION AND RENIN RELEASE

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