Response of the Stroke Volume and Blood Pressure of Young Patients With Nonobstructive Hypertrophic Cardiomyopathy to Exercise

概要

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Stroke volume (SV), cardiac output (CO) and systolic blood pressure (SBP) were measured during maximal symptom-limited bicycle exercise testing in 13 young patients (age, 11-26 years) with nonobstructive hypertrophic cardiomyopathy (HCM). SV was measured by impedance plethysmocardiography; %SV_<end>, %CO_<end>, and %SBP_<end> represent the ratio of the value at termination of the exercise to the respective value at rest. In all patients of HCM-I (the Cardiac Event Group, 3 patients) and 3 of HCM-II (the Non-Cardiac Event Group, 10 patients), the %SV_<end> was less than 100%. The %SV_<end> of HCM-I was significantly lower than the respective values of the HCM-II and Control groups. The %CO_<end> values of the HCM-I and HCM-II groups were each significantly lower than that of the Control. The %SBP_<end> values of the HCM-I and HCM-II groups were each significantly lower than that of the Control. Among the HCM patients, the %SV_<end> value was positively correlated with the %SBP_<end> value. The patients who had more sever HCM had poorer execise-induced increases in SV and SBP. These results suggest that sudden cardiac death in young HCM patients is associated with inhibition of the increase in SV upon exercise.
社団法人日本循環器学会の論文
2001-03-20