Effects of Angiotensin II on the Renal Interstitial Concentrations of NO_2/NO_3 and Cyclic GMP in Anesthetized Rats

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概要

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• The present study was conducted to determine whether exogenous angiotensin II (Ang II) may increase the renal interstitial fluid concentrations of NO2/NO3 (NOx) and cyclic guanosine monophosphate (cGMP) concomitantly and which Ang II receptor subtypes may induce these changes in anesthetized rats, using a microdialysis method. Ang II (50 ng/kg per min, i.v.) significantly increased mean blood pressure (MBP), extraction rates of renal interstitial NOx from 23.9 ± 1.0 to 31.2 ± 1.9 pmol/min, and cGMP from 4.1 ± 0.3 to 6.4 ± 0.5 fmol/min, and decreased renal blood flow (RBF). The AT1-receptor antagonist CV11974 alone significantly increased RBF, but did not alter MBP, renal interstitial concentrations of NOx and cGMP. A superimposition of Ang II on CV11974 did not affect MBP and RBF, but significantly increased renal interstitial concentrations of NOx and cGMP. The AT2-receptor antagonist PD123319 alone did not change any of the parameters. However, superimposition of Ang II on PD123319 increased MBP and decreased RBF without any effects on renal interstitial concentrations of NOx and cGMP. These results suggest that Ang II stimulates NO production via the AT2-receptor in the kidney.

• 社団法人 日本薬理学会の論文
• 2002-04-01

著者

• 木村 正司

  Department Of Pharmacology Kagawa Medical University

• KIMURA Shoji

  Department of Pharmacology, Kagawa University Medical School

• ABE Youichi

  Department of Pharmacology, Kagawa University Medical School

• RAHMAN Matlubur

  Department of Pharmacology, Kagawa Medical University

• NISHIYAMA Akira

  Department of Pharmacology, Kagawa Medical University

• YONEYAMA Hirohito

  Departments of Physiology, Kagawa Medical University

• KOSAKA Hiroaki

  Departments of Physiology, Kagawa Medical University

• FUKUI Toshiki

  Departments of Pharmacology, Kagawa Medical University

• 木村 正司

  香川医大・薬理

• Kagami Shoji

  Department Of Pediatrics The University Of Tokushima Graduate School Of Medical Sciences

• Fukui Toshiki

  Departments Of Pharmacology Kagawa Medical University

• Fukui Toshiki

  Department Of Decommissioning And Waste Management Japan Atomic Energy Research Institute

• Rahman Matlubur

  Department Of Pharmacology Kagawa Medical University

• Kimura Shoji

  Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University

• Nishiyama Akira

  Department Of Pharmacology Kagawa University Medical School

• Nishiyama Akira

  Advanced Lsi Technology Laboratory Corporate Research & Development Center Toshiba Corporation

• Youichi Abe

  Department Of Pharmacology Kagawa University Medical School

• Abe Youichi

  Department Of Pharmacology Kagawa Medical University

• Abe Youichi

  Departments Of Kagawa Medical School Neurological Surgery Pharmacology

• Kobori Hiroyuki

  Department Of Physiology Tulane University Health Sciences Center

• Kosaka Hiroaki

  Department Of Cardiovascular Physiology Faculty Of Medicine Kagawa University

• Nishiyama Akira

  Department Of Pharmacology Faculty Of Medicine Kagawa University

• Nishiyama Akira

  Faculty Of Medicine Department Of Pharmacology Kagawa University

• Kimura S

  The Department Of Pharmacology Kagawa Medical School

• Yoneyama Hirohito

  Department Of Gastroenterology And Neurology Kagawa University School Of Medicine

• Yoneyama Hirohito

  Departments Of Physiology Kagawa Medical University

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