Antioxidant Effects of Photodegradation Product of Nifedipine

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概要

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• Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. Nifedipine is unstable under light and reportedly decomposes to a stable nitrosonifedipine (NO-NIF). NO-NIF has no antihypertensive effect, and it has been recognized as a contaminant of nifedipine. The present study for the first time demonstrated that NO-NIF changed to a NO-NIF radical in a time-dependent manner when it interacted with human umbilical vein endothelial cells (HUVECs). The electron paramagnetic resonance (EPR) signal of NO-NIF radicals in HUVECs showed an asymmetric pattern suggesting that the radicals were located in the membrane. The NO-NIF radicals had radical scavenging activity for 1,1-diphenyl-2-picrylhydrazyl, whereas neither NO-NIF nor nifedipine did. In addition, the NO-NIF radical more effectively quenched lipid peroxides than NO-NIF or nifedipine. Furthermore, NO-NIF attenuated the superoxide-derived free radicals in HUVECs stimulated with LY83583, and suppressed iron-nitrilotriacetic acid (Fe-NTA)-induced cytotoxicity in rat pheochromocytoma (PC12) cells. Our findings suggest that NO-NIF is a candidate for a new class of antioxidative drugs that protect cells against oxidative stress.

著者

• YOSHIDA Masahiro

  Department of Applied Chemistry and Chemical Engineering

• Tomita Shuhei

  Department Of Pharmacology The Institute Of Health Bioscience The University Of Tokushima Graduate S

• Tamaki Toshiaki

  Department of Pharmacology, IHBS, the University of TOKUSHIMA Graduate school

• ISHIZAWA Keisuke

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• KAWAZOE Kazuyoshi

  Department of Pharmacy, Tokushima University Hospital

• TSUCHIYA Koichiro

  Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences

• Ikeda Yasumasa

  Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of He

• Ikeda Yasumasa

  Department Of Cardiology Tokushima Prefectural Central Hospital

• Horinouchi Yuya

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Taoka Chiaki

  Department of Medical Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Tajima Soichiro

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Kihira Yoshitaka

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Matsuda Yuko

  Department of Medical Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Shishido Kozo

  Department of Synthetic Organic Chemistry, The Institute of Health Bioscience, The University of Tok

• Hamano Shuichi

  Department of Pathological Science and Technology, The Institute of Health Bioscience, The Universit

• Tamaki Toshiaki

  Department Of Pharmacology Kagawa Medical School

• Ishizawa Keisuke

  Department Of Neurology Neurological Institute Tokyo Women's Medical College

• Tsuchiya Koichiro

  Department Of Clinical Pharmacology Institute Of Health Biosciences The University Of Tokushima Grad

• Kawazoe Kazuyoshi

  Department Of Clinical Pharmacy Institute Of Health Biosciences The University Of Tokushima Graduate

• Kihira Yoshitaka

  Department Of Neural And Pain Sciences Program In Neuroscience University Of Maryland:faculty Of Pha

• Kitaichi T

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Kitaichi T

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Ishizawa Keisuke

  Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu

• Tajima Soichiro

  Department Of Pharmacology Institute Of Health Biosciences The University Of Tokushima Graduate Scho

• Tsuchiya Koichiro

  Department Of Cardiovascular Surgery The University Of Tokushima Graduate School Of Health Bioscienc

• Yoshida Masahiro

  Department Of Applied Bioorganic Chemistry Gifu University

• Shishido Kozo

  Department of Synthetic Organic Chemistry, The Institute of Health Bioscience, The University of Tokushima

• Tsuchiya Koichiro

  Department of Medical Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Hamano Shuichi

  Department of Pathological Science and Technology, The Institute of Health Bioscience, The University of Tokushima

• Tamaki Toshiaki

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

• Ikeda Yasumasa

  Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima

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