Apoptosis Induction Associated with Cell Cycle Dysregulation by Rice Bran Agglutinin.
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概要
- 論文の詳細を見る
Effects of rice bran agglutinin (RBA) on human monoblastic leukemia U937 cells wereexamined in comparison with those of wheat germ agglutinin (WGA) and Viscum album agglutinin (VAA). These lectins inhibit cell growth, and several lines of evidence indicatethat the growth inhibition is caused by the induction of apoptosis. We observed thatRBA induces chromatin condensation, externalization of membrane phosphatidylserine, and DNA ladder formation, features of apoptosis. DNA ladder formation was inhibitedby a general inhibitor against caspases, which are known to play essential roles in apoptosis. Flow cytometric analysis revealed that RBA and WGA cause G2IM. phase cell cyclearrest with increased expression of Wafl/p21, while cell cycle arrest was not observedfor VAA. These data indicate that RBA induces apoptosis associated with cell cyclearrest in U937 cells, and suggest that the induction mechanism for RBA is similar to thatfor WGA, but different from that for VAA.
- 社団法人 日本生化学会の論文
著者
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Koyama Yu
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Mita Takashi
Laboratories Of Biochemistry School Of Food And Nutritional Sciences The University Of Shizuoka
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Miyoshi Noriyuki
Laboratory Of Biochemistry Global Coe Program For Innovation In Human Health Sciences Department Of
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KATSUNO Yuko
Laboratory of Cellular Biochemistry, Graduate School of Nutritional and Environmental Sciences, Univ
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HAYAKAWA Sumio
Laboratory of Cellular Biochemistry, Graduate School of Nutritional and Environmental Sciences, Univ
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Ohta Toshiro
Laboratory Of Cell And Molecular Biology Of Aging Graduate School Of Nutritional And Environmental S
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Kaji Kazuhiko
Laboratory Of Cell And Molecular Biology Of Aging And Coe Program In The 21st Century Department Of
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Isemura Mamoru
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Katsuno Yuko
Laboratory of Cellular Biochemistry, University of Schizuoka
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