Optical Resolution of 2,2,2-Trifluoro-1-(9-Phenanthryl)Ethanol via Enzymatic Alcoholysis of Its Activated Ester

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概要

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• Practical lipase LIP (Pseudomonas aeruginosa)-catalyzed optical resolution of 2,2,2-trifluoro-1-(9-phenanthryl)ethanol (TEPE), which is a sterically hindered secondary alcohol, has been performed. The method was used effectively for the first enzymatic preparation of both enantiomers of TFPE via lipase-catalyzed enantioselective alcoholysis of its chloroacetate ester. A simple procedure was developed for separating the S-alcohol product from the unreactive R-chloroacetate ester and for hydrolyzing the latter to obtain the R-alcohol. Using a similar procedure, the optical resolution of 2,2,2-trifluoro-1-(1-naphthyl)ethanol (TFNE) was achieved as well.

• 社団法人日本生物工学会の論文
• 1996-03-25

著者

• KATO Katsuya

  Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University

• KATO Katsuya

  National Institute of Advanced Industrial Science and Technology (AIST)

• KIMOTO Hiroshi

  Department of lmmunology, National lnstitute of Health of Japan

• FUJII SHOZO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• KATAYAMA MASATO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Fujii Shozo

  Department Of Chemistry National Industrial Research Institute Of Nagoya

• Katayama Masato

  Department Of Agricultural Chemistry Nagoya University

• Kimoto H

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Fukaya H

  Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn

• Fukaya Haruhiko

  Department Of Chemistry National Industrial Research Institute Of Nagoya

• Kimoto Hiroshi

  Department Of Immunology Japnese Institute Of Infectious Diseases

• Kato Katsuya

  National Industrial Research Insitute Of Nagoya

• Katayama M

  Cooperative Research Laboratory For Plant Growth Regulator Development National Institute Of Advance

• Kato K

  National Institute Of Advanced Industrial Science And Technology (aist)

• Kato Katsuya

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

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