Lipase-Catalyzed Optical Resolution of 2,2,2-Trifluoro-1-(Indole-3-)Ethanols in Organic Solvents

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概要

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• As a result of screening 19 enzymes, lipase AK (a lipase from Pseudomonas sp.) was found to be suitable for the optical resolution of 2,2,2-trifluoro-1-(indole-3-)ethanol (TFIE). The combination of two lipase AK-catalyzed reactions gave S-(+)-TFIE and R-(-)-TFIE with 97% e.e. and 95% e.e., respectively. The conditions determined as optimum for the reactions were in octane at 45℃ for 8 h, and using vinyl acetate for acetylation and using propanol for alcoholysis. In case of TFIEs with a methyl group on the indole nucleus, the enantioselectivity of lipase AK increases when the methyl group is far from the chiral center.

• 社団法人日本生物工学会の論文
• 1994-07-25

著者

• KATO Katsuya

  Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University

• KATO Katsuya

  National Institute of Advanced Industrial Science and Technology (AIST)

• KIMOTO Hiroshi

  Department of lmmunology, National lnstitute of Health of Japan

• FUJII SHOZO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• KATAYAMA MASATO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Fujii Shozo

  Department Of Chemistry National Industrial Research Institute Of Nagoya

• Katayama Masato

  Department Of Agricultural Chemistry Nagoya University

• Kimoto H

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Kimoto Hiroshi

  Department Of Immunology Japnese Institute Of Infectious Diseases

• Kato Katsuya

  National Industrial Research Insitute Of Nagoya

• GAUTAM RAKESH

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Katayama M

  Cooperative Research Laboratory For Plant Growth Regulator Development National Institute Of Advance

• Kato K

  National Institute Of Advanced Industrial Science And Technology (aist)

• Gautam R

  Laboratory Of Bioorganic Chemistry Department Of Chemistry National Industrial Research Institute Of

• Kato Katsuya

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

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