Preparation of Optically Active Trifluoromethylated (3′-Indolyl) Thiacarboxylic Acids, Novel Plant Growth Regulators, through Lipase-Catalyzed Enantioselective Hydrolysis

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概要

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• Among a variety of lipases tested, that obtained from Candida antarctica(SP 435) induced enantioselective hydrolysis of trifluoroethyl 5, 5, 5-trifluoro-4-(3′-indolyl)-3-thiapentanoate(1c). The selectivity could be increased by optimizing the reaction conditions. Thus, good selectivity was achieved(E=37) in a buffer containing 10% dichloroethane. In order to improve the optical yields, a sequential kinetic resolution was utilized for the preparative-scale enantioselective hydrolysis of 1c using SP 435. Hydrolysis of trifluoroethyl 6, 6, 6-trifluoro-5-(3′-indolyl)-4-thiahexanoate(2c) with the lipase of Pseudomonas aeruginosa(LIP) in a buffer containing 20% tert-amyl alcohol at 25℃ gave excellent selectivity(E=357).

• 社団法人日本生物工学会の論文
• 1999-01-25

著者

• KATO Katsuya

  Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University

• Tanaka S

  National Industrial Research Insitute Of Nagoya

• KATO Katsuya

  National Institute of Advanced Industrial Science and Technology (AIST)

• KIMOTO Hiroshi

  Department of lmmunology, National lnstitute of Health of Japan

• TANAKA SATOKO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• FUJII SHOZO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• KATAYAMA MASATO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Fujii Shozo

  Department Of Chemistry National Industrial Research Institute Of Nagoya

• Katayama Masato

  Department Of Agricultural Chemistry Nagoya University

• Kimoto H

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Kimoto Hiroshi

  Department Of Immunology Japnese Institute Of Infectious Diseases

• Kato Katsuya

  National Industrial Research Insitute Of Nagoya

• Katayama M

  Cooperative Research Laboratory For Plant Growth Regulator Development National Institute Of Advance

• Kato K

  National Institute Of Advanced Industrial Science And Technology (aist)

• Kato Katsuya

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

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