Eficient Preparation of Optically Active Ketoprofen by Mucor javanicus Lipase Immobilized on an Inorganic Support

スポンサーリンク

概要

• 論文の詳細を見る

• Lipase M from Mucor javanicus, one of nine commercially available hydrolytic enzymes, showed good enantioselectivity (E=50) for racemic ketoprofen trifluoroethyl ester in phosphate buffer (pH 7.0) containing 30% acetone. Lipase M immobilized on Toyonite 200-A showed the best selectivity (E=55) and reactivity.Moreover, the lipase could be recycled at least 5 times.

• 社団法人日本生物工学会の論文
• 2000-09-25

著者

• SAITO Takao

  Department of Materials Chemistry , Graduate School of Osaka University

• KATO Katsuya

  Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University

• KATO Katsuya

  National Institute of Advanced Industrial Science and Technology (AIST)

• KIMOTO Hiroshi

  Department of lmmunology, National lnstitute of Health of Japan

• Kimoto H

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Saito Terumi

  National Institute Of Advanced Industrial Science And Technology (aist)

• Gong Yuefa

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Kimoto Hiroshi

  Department Of Immunology Japnese Institute Of Infectious Diseases

• GONG YUEFA

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Gong Yuefa

  Department Of Chemistry University Of Tsukuba

• Kato Katsuya

  National Industrial Research Insitute Of Nagoya

• Kato K

  National Institute Of Advanced Industrial Science And Technology (aist)

• Saito Takao

  Department Of Gastroenterological Surgery National Kyushu Cancer Center

• Kato Katsuya

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

• Saito Takao

  Department Of Biochemistry And Surgery Oita Medical School

• Saito Takao

  Department Of Chemistry National Industrial Research Institute Of Nagoya

関連論文

• Crystal Structure of Long Alkyl 3-(Thymin-1-yl)propionates: Style of Hydrogen Bonding and Dependence on the Alkyl Chain Length
• Local Electronic Structure and Protonic Conductivity in Perovskite-Type Oxide, SrZrO_3
• 09-O-07 Changes in Electrical Conductivity of ZnO with Hydrogen Implantation
• Enzyme encapsulation in silica particles prepared using enzyme-assisted sol–gel reactions in ionic liquids
• Prognostic Significance of Loss of Heterozygosity on Chromosome 9p21-22 in Human Esophageal Cancer
• Assessment of mean transit time in the engrafted lung with ^Xe lung ventilation scintigraphy improves diagnosis of bronchiolitis obliterans syndrome in living-donor lobar lung transplant recipients
• Computed tomography findings of congenital generalized lipodystrophy : multiple nodular fatty liver and diffuse sclerosis of bones
• Recurrent Lung Cancer in the Mediastinum Noticed after a Living-Donor Lobar Lung Transplantation
• Expression of V_3(8HS-20)molecules by alternative RNA processing
• Expression of a Thermostable Cellulase Gene from a Thermophilic Anaerobe in Saccharomyces cerevisiae
• Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsiveness
• BASIC STUDY ON MEMBRANE-ACTIVE AGENTS THAT POTENTIATE ANTICANCER ANTIBIOTICS
• Reversible Photodimerization of Ester Derivatives of Thymine Having Long Alkyl Chains in Solid Film
• Crystal Sturcture of 2-Ethoxy-6, 13-dimethoxy-12-methyl-11-phenyl-9, 11, 13, 15-tetraazatetracyclo[7.6.0.0^.0^]pentadeca-3, 4, 6-triene-10, 14-dione
• Crystal Structure of 5-(Dibenzylamino)-8-methoxy-4a-[1-(methoxyimino)ethyl]-2-phenyl-4a, 5-dihydro[1, 3, 5]triazino[1, 2-a]indole-1, 3(2H, 4H)-dione
• Preparation of Optically Active Trifluoromethylated (3′-Indolyl) Thiacarboxylic Acids, Novel Plant Growth Regulators, through Lipase-Catalyzed Enantioselective Hydrolysis
• A Case of Sudden Unexplained Nocturnal Death from Overlooked Brugada Syndrome at a Pre-employment Check-up
• Immobilization of antibodies on mesoporous silica materials and their binding abilities to antigens
• Overproduction of Thermostable β-Galactosidase in Escherichia coli, Its Purification and Molecular Structure
• Characterization of Third 3-Hydroxybutyrate Dehydrogenase in Ralstonia pickettii T1
• Reaction Properties of Catalytic Antibodies Encapsulated in Organo Substituted SiO_2 Sol-Gel Materials(BIOCHEMICAL ENGINEERING)
• Detoxification of Bisphenol A and Nonylphenol by Purified Extracellular Laccase from a Fungus Isolated from Soil(ENVIRONMENTAL BIOTECHNOLOGY)
• Biochemical and Genetic Characterization of a D(-)-3-Hydroxybutyrate Dehydrogenase from Acidovorax sp. Strain SA1
• Catalytic Triad of Intracellular Poly(3-Hydroxybutyrate) Depolymerase(PhaZ1) in Ralstonia eutropha H16
• Catalytic Properties of Lipases Immobilized on Various Mesoporous Silicates(Microbiology & Fermentation Technology)
• Preparation and Catalytic Performance of Lipases Encapsulated in Sol-Gel Materials(Microbiology & Fermentation Technology)
• Eficient Preparation of Optically Active Ketoprofen by Mucor javanicus Lipase Immobilized on an Inorganic Support
• BF_3-Promoted Aromatic Substitution of N-Alkyl α-Trifluoromethylated Imine: Facile Synthesis of 1-Ary1-2,2,2-trifluoroethylamines
• Regioselective Substitution of Phenols with Trifluoroacetaldehyde Ethyl Hemiacetal
• Crystal Structure of N-Acetyl-β-trifluoromethyltryptophan Ethyl Acetate
• Substitution of Five-Membered Heteroarenes and Uracils with Trifluoroacetaldehyde Ethyl Hemiacetal
• Crystal Structure of Ethyl 4, 4, 4-Trifluoro-2-hydroxy-2-carbethoxy-3-(indol-3-yl)butyrate
• Enzymatic Resolution of 2, 2, 2-Trifluoro-1-(1-pyrenyl) ethanol with Lipases
• Effective Preparation of Optically Active 4,4,4-Trifluoro-3-(Indole-3-)Butyric Acid, a Novel Plant Growth Regulator, Using Lipase from Pseudomonas fluorescens
• Optical Resolution of 2,2,2-Trifluoro-1-(9-Phenanthryl)Ethanol via Enzymatic Alcoholysis of Its Activated Ester
• Optical Resolution of 1-Arylethanols with a Condensed Aromatic Ring by Lipase from Pseudomonas aeruginosa
• A Facile Preparation of Enantiomers of Ethyl 4,4,4-Trifluoro-3-(Indole-3-)Butyrate, a Novel Plant Growth Regulator
• Preparation and Lipase-catalyzed Optical Resolution of 2,2,2-Trifluoro-1-(naphthyl)ethanols
• Lipase-Catalyzed Optical Resolution of 2,2,2-Trifluoro-1-(Indole-3-)Ethanols in Organic Solvents
• Lipase-catalyzed Optical Resolution of 2,2,2-Trifluoro-1-(1-naphthyl)ethanol
• Enzymatic Preparation of Both Enantiomers of 4,4,4-Trifluoro-3-(Indole-3-)Butyric Acid, a Novel Plant Growth Regulator
• Utility of FDG-PET in differential diagnosis of benign and malignant fractures in acute to subacute phase
• Nucleotide Sequence of the LacN Gene Encoding Thermostable β-Galactosidase of a Thermophilic Anaerobe, Strain NA10
• Staurosporine Promotion of Formation of Continuous Monolayers of Primary Rat Hepatocytes by Improving Attachment and Spreading
• Long-term Culture of Primary Rat Hepatocytes on Heparin- or Lambda Carrageenan-containing Collagen Gels
• DNA Fragmentation Induced in High-Cell-Density Culture of Primary Rat Hepatocytes In an Active Process Dependent on Energy Availability, Gene Expression, and Calmdulin
• Inhibition by Retinoic Acid of Albumin and DNA Synthesis in Adult Rat Hepatocytes
• Inhibition by Apple Polyphenols of ADP-Ribosyltransferase Activity of Cholera Toxin and Toxin-Induced Fluid Accumulation in Mice
• Appendiceal Intussusception Due to an Appendiceal Malignant Polyp-An Association in a Patient with Peutz-Jeghers Syndrome : Report of a Case
• FDG PET in the clinical evaluation of sarcoidosis with bone lesions
• Malignant Hypertension and Microangiopathic Hemolytic Anemia
• Mycobacterium kansasii Osteomyelitis in a Patient with AIDS on Highly Active Antiretroviral Therapy
• Catalytic activity of aryl alcohol oxidase immobilized in 3D-mesoporous silicates(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• Enhancing activity and stability of Burkholderia cepacia lipase by immobilization on surface-functionalized mesoporous silicates(BIOCHEMICAL ENGINEERING)
• Crystal Structure of 2-Deoxyascorbic Acid
• One-Way Photoisomerization of Dienes Substituted by an Anthracene Nucleus
• Crystal Structure of 5, 5, 6, 7, 8-Pentafluoro-6-methoxy-5, 6, 7, 8-tetrahydroquinoline
• Crystal Structure of 5-Chloro-2-(trifluoromethyl)-2,3-dihydrobenzimidazole : One of a New Class of Herbicidal Compounds
• Crystal Structure of 2-Methoxy-2-(trifluoromethyl)tetrahydroimidazole-4, 5-dione
• Crystal Structure of(+)-2, 2, 2-Trifluoro-1-(9-phenanthryl)ethyl S-O-Methylmandelate : Determination of the Absolute Configuration of the(+)-Carbinol
• Preparation and catalytic evaluation of cytochrome c immobilized on mesoporous silica materials
• A Modified Colorimetric MTT Assay Adapted for Primary Cultured Hepatocytes : Application to Proliferation and Cytotoxicity Assays
• Preparation and Reactions of 1,2-Thiaphospholes
• Microbial Production of Hydroxy-C_-Steroids as Estrogen Synthetase (P-450・Aromatase) Inhibitors : Studies on Mixrobial Transformation (XXX).
• The Swelling of the External Ear in an Old Woman
• ENTRAPMENT NEUROPATHY OF RADIAL NERVE : A REVIEW OF 4 CASES
• Significance of fat stains in serial sections from Epon-embedded tissue samples for electron microscopy in renal diseases
• 1,8-Diazabicyclo[5.4.0]undec-7-ene-promoted Regioselective Elimination of Vicinal Dibromides Having an Adjacent O- and/or N-Functional Group
• A Definite Case of L-carbocisteine-induced Pneumonia with CATCH22 Syndrome
• Chemistry of 1,2-thiaphosphole 2-sulfides. II. Reactions of 1,2-thiaphosphole 2-sulfides with some nucleophiles.
• Chemistry of 1,2-thiaphosphole 2-sulfides. I. Cycloaddition reactions of 1,2-thiaphosphole 2-sulfides with some dienophiles.
• Crystal and molecular structure of 3,8-di-t-butyl-5,6-diphenyl-1-thioxo-2,9-dithia-1-phosphabicyclo(4.3.0)nona-3,7-diene.
• Crystal and molecular structure of 4-t-butyl-5-cyano-2-phenyl-1-thioxo-7-thia-1-phosphabicyclo(2.2.1)hept-2-ene.
• Reactions of .ALPHA.,.BETA.-unsaturated thiones with diphenylcyclopropenone and diphenylcyclopropenethione.
• The reaction of fluorenethione S-tosylimide with Grignard reagents.
• Thione S-imide. Reaction with heterocumulenes.
• The Reaction of Isocyanates with Carboxylic Acids and Thiocarboxylic Acids
• Thione S-imides. The reaction with carbon-hetero atom double bond.
• The Wittig-type reaction of O=C-, C=C-, and N=C-substituted methylenetriphenylphosphoranes with N-sulfinyl-p-toluenesulfonamide. An intramolecular 1,3-dipolar cyclization of imidoyl-conjugated thione S-imides.

もっと見る 閉じる

スポンサーリンク