Microbial Production of Hydroxy-C_<19>-Steroids as Estrogen Synthetase (P-450・Aromatase) Inhibitors : Studies on Mixrobial Transformation (XXX).
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概要
- 論文の詳細を見る
Four monohydroxy derivatives of androst-4-ene-3,17-dione (4AD) and two of andorost-4-ene-3,6,17-trione (4AT), derived from microbial transformation of 4AD and 4AT, were purified and identified by UV, IR, mass, ^<13>C-NMR, and ^1H-NMR spectroanalyses. These derivatives were evaluated as inhibitors of human placentalaromatase. They showed dose-dependent inactivation of aromatase in the presence of reduced nicotinamide adenine dinucleotide phosphate. Among them, 6α-hydroxyandrost-4-ene-3,17-dione (6α-OH-4AD) was the most potent, exhibiting 97.8% inhibition at 100 μM; this value was 1.04-fold higher than the inhibition shown by 4AT (93.6%). The other derivatives, 16β-OH-4AT, 15α-OH-4AD, 15β-OH-4AD, 6β-OH-4AD and 12α-OH-4AT, inhibited the aromatase 80.4%, 63.6%, 61.8%, 30.1%, and 9.6%, respectively, at the same concentration.
- 公益社団法人日本生物工学会の論文
- 1995-09-25
著者
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KATO Katsuya
Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University
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NAKAMURA Junji
Research Institute of Life Science, Snow Brand Milk products Co., Ltd.
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Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
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Nakamura J
Research Institute Of Life Science Snow Brand Milk Producs Co. Ltd.
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Mineki Shigeru
Department Of Applied Biological Science Faculty Of Sciecne And Technology Science University Of Tok
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Kita Kazuhiro
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Yoshihama Makoto
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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FUKAYA FUYUKI
Department of Applied Biological Science, Faculty of Science and Technology, Science University of T
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Nakamura Junji
Research Institute Of Life Science Snow Brand Milk Producs Co. Ltd.
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Fukaya Fuyuki
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Kato Katsuya
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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