Microbial Degradation of 19-Hydroxy-Sterol Side Chains : Studies on Microbial Transformation (XXVI).
スポンサーリンク
概要
- 論文の詳細を見る
Experimental evidence is herein presented to show that C_<22> acids are key intermediates in the microbial degradation of cholesterol and campesterol (β-sitosterol) side chains. Exposure of 19-hydroxy-sterols to Rhodococcus mutant K-3 gave four new steroid carboxylic acids in addition to that known as estrone (P1); the chemical structures of these metabolites were characterized as 2(3-hydroxy-1,3,5(10)-estratrien-170yl)-propionic acid (P2), 2-methyl-6(3-hydroxy-1,3,5(10)-estratrien-17-yl)-heptanoic acid(P3), 2,3-dimethyl-6(3-hydroxy-1,3,5(10)-estratrien-17-yl)-hyptanoic acid (P4), and 2(3-hydroxy-1,3,5(10), 17-estratetraen-17-yl)-propionic acid (P5). We propose a degradation pathway of 19-hydroxy-cholesterol and campesterol (β-sitosterol) side chains.
- 公益社団法人日本生物工学会の論文
- 1993-01-25
著者
-
IIDA MITSUGI
Department of Applied Biological Science, Science University of Tokyo
-
Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
-
Murohisa T
Department Of Applied Biological Science Science University Of Tokyo
-
Murohisa Tomoo
Department Of Applied Biological Science Science University Of Tokyo
関連論文
- A New Cerebroside of the n-Alkane-Assimilating Yeast Candida deformans
- Microbial Polyhydroxylation of Progesterone by Acremonium strictum
- Microbial Production of Two New Dihydroxylated Androstenedione Derivatives by Acremonium strictum
- Microbial Formation of Lumisantonin from (-)-α-Santonin : Studies on Microbial Transformations (XX)
- Microbial Hydroxylation of 11,13-Dehydrosantonin by Aspergillus niger : Studies on Microbiological Transformation (XXVIII).
- Microbial Hydroxylation of (-)-α-Santonin by Aspergillus niger : Studies on Microbial Transformations(XXIV)
- Effect of n-Alkanes on Cellular Non-Polar Lipids in Mucor sp.
- Effects of n-Alkanes on Compositions of Cellular Non-Polar Lipids in Aspergillus sp.Isolated from Solid
- Phospholipid Derived from Hydrocarbons by Fungi
- Some New Intermediates in Microbial Side Chain Degradation of β-Sitosterol : Studies on Microbial Transformation (XXVII).
- Purification and Characterizatioin of Extracellular Poly(3-Hydroxybutyrate) Depolymerases Produced by Agrobacterium sp. K-03
- Cloning, Nucleotide Sequencing, and Expression in Escherichia coli of the Gene for Formate Dehydrogenase of Paracoccus sp. 12-A, a Formate-assimilating Bacterium(Biochemistry & Molecular Biology)
- Microbial Production of Hydroxy-C_-Steroids as Estrogen Synthetase (P-450・Aromatase) Inhibitors : Studies on Mixrobial Transformation (XXX).
- Purification and Characterization of a NAD^+-Dependent Formate Dehydrogenase Produced by Paracoccus sp.
- Microbiological Production of 20-Carboxy-Pregna-1,4-Dien-3-One from β-Sitosterol with High Yield by a Rhodococcus Species : Studies on Microbial Transformations (XXII)
- Microbial Degradation of 19-Hydroxy-Sterol Side Chains : Studies on Microbial Transformation (XXVI).
- Candicin, a New Sphingoglycolipid from Hydrocarbon-Assimilating Yeast
- Production of 20-Carboxy-Pregna-1,4-Dien-3-One from Sterols by Mutants of Rhodococcus sp. : Studies on Microbial Transformations (XXIII)
- INFLUENCE OF STEROID STRUCTURE ON THE 16α-HYDROXYLATION ACTIVITY OF STEROID BY MICROORGANISM (STUDIES ON MICROBIAL TRANSFORMATIONS.XVII)