Microbial Hydroxylation of 11,13-Dehydrosantonin by Aspergillus niger : Studies on Microbiological Transformation (XXVIII).
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概要
- 論文の詳細を見る
The microbial tranformation of a sesquiterpene lactone, 11,13-dehydro-(-)-α-santonin (DS), was carried out by 7 fungi. Although 6 of the fungi transformed the substrate into three (one fungus) of fewer (5 fungi) kinds of products, Aspergillus niger MIL 5024 gave five products including all of those produced by the others. The products were identified by UV, IR, mass, and ^1H-NMR spectroanalyses as (-)-α-santonin (P1), 11-hydroxy-(-)-α-santonin (P2), 13-hydroxy-(-)-α-santonin (P3), 3,6,9-trihydroxy-9,10-seco-selina-1,3,5(10)-trien-12-oic acid-12,6-lactone (P4), and 8-epi-artemisin (P5). P3,a new compound, was also produced by A. niger MIL 5035,but P4 and P5 were produced only by strain MIL 5024. The biosynthetic pathway of these 5 products from DS was estimated.
- 社団法人日本生物工学会の論文
- 1993-10-25
著者
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YAMAKAWA Koji
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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MINEKI Shigeru
Department of Parasitology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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IIDA MITSUGI
Department of Applied Biological Science, Science University of Tokyo
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Iida M
Sci. Univ. Tokyo Noda Jpn
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Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
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Mineki S
Sci. Univ. Tokyo Chiba Jpn
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Mineki Shigeru
Department Of Applied Biological Science Faculty Of Sciecne And Technology Science University Of Tok
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Yamakawa K
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Wakuri Shinobu
Department Of Applied Biological Science Science University Of Tokyo
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Iida M
Sci. Univ. Tokyo Chiba Jpn
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Yamakawa K
Department Of Quantum Engineering Nagoya University
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NISHITANI KIYOSHI
Faculty of Pharmaceutical Science, Science University of Tokyo
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Yamakawa Koji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Yamakawa Koji
Faculty Of Pharmaceutical Science Science University Of Tokyo
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Nishitani Kiyoshi
Faculty Of Pharmaceutical Science Science University Of Tokyo
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