Effective Preparation of Optically Active 4,4,4-Trifluoro-3-(Indole-3-)Butyric Acid, a Novel Plant Growth Regulator, Using Lipase from Pseudomonas fluorescens

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概要

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• Optical resolution of 4,4,4-trifluoro-3-(indole-3-)butyric acid (TFIBA), a novel plant growth regulator, was achieved by Pseudomonas fluorescens lipase (lipase AK)-catalyzed enatioselective hydrolysis of its trifluoroethyl ester. Compared with the reactivity of lipase AK for TFIBA ethyl ester, that for TFIBA trifluoroethyl ester was markedly increased, and the reaction was complete within 1 h at 40℃ in phosphate buffer containing 10% tert-amyl alcohol. The reactivity of lipase AK for TFIBA trifluoroethyl ester was similar to that for two other TFIBA esters (fluoroethyl and difluoroethyl), and higher than that for other esters (chloroethyl, trichloroethyl, and tribromoethyl). These results suggest that the introduction of fluorine atom(s) into an alcoholic group is an effective way to increase the rate of hydrolysis by lipase AK.

• 社団法人日本生物工学会の論文
• 1996-10-25

著者

• KATO Katsuya

  Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya University

• KATO Katsuya

  National Institute of Advanced Industrial Science and Technology (AIST)

• KIMOTO Hiroshi

  Department of lmmunology, National lnstitute of Health of Japan

• FUJII SHOZO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• KATAYAMA MASATO

  Department of Chemistry, National Industrial Research Institute of Nagoya

• Fujii Shozo

  Department Of Chemistry National Industrial Research Institute Of Nagoya

• Katayama Masato

  Department Of Agricultural Chemistry Nagoya University

• Kimoto H

  National Institute Of Advanced Industrial Scienec And Technology (aist)

• Kimoto Hiroshi

  Department Of Immunology Japnese Institute Of Infectious Diseases

• Kato Katsuya

  National Industrial Research Insitute Of Nagoya

• Katayama M

  Cooperative Research Laboratory For Plant Growth Regulator Development National Institute Of Advance

• Kato K

  National Institute Of Advanced Industrial Science And Technology (aist)

• Kato Katsuya

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

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