Combination of Poly(ethylenimine) and Chitosan Induces High Gene Transfection Efficiency and Low Cytotoxicity(MISCELLANEOUS)
スポンサーリンク
概要
- 論文の詳細を見る
In this study, the cytotoxicity and transfection efficiency of using chitosan/DNA complex combined with poly(ethylenimine) (PEI) were investigated. The combination of PEI with the chitosan/DNA complex markedly enhanced the gene expression of HeLa cells to 1000-fold of that induced by chitosan alone. PEI's cytotoxicity was considerably decreased upon combination with the chitosan/DNA complex. Furthermore, the PEI/chitosan/DNA could maintain the gene expression efficiency in the presence of serum.
- 社団法人日本生物工学会の論文
- 2008-01-25
著者
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tabata yasuhiko
Department of Biomaterials, Institute for Frontier Medical Science, Kyoto university
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Chen Jin-liang
College Of Pharmaceutical Sciences Zhejiang University
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ZHAO Qing-Qing
College of Pharmaceutical Sciences, Zhejiang University
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LIANG Wen-Quan
College of Pharmaceutical Sciences, Zhejiang University
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GAO Jian-Qing
College of Pharmaceutical Sciences, Zhejiang University
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Han Min
College of Pharmaceutical Sciences, Zhejiang University
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Gao Jian-qing
College Of Pharmaceutical Sciences Zhejiang University
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He Cai-li
College Of Pharmaceutical Sciences Zhejiang University
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Han Min
College Of Pharmaceutical Sciences Zhejiang University
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Zhao Qing-qing
College Of Pharmaceutical Sciences Zhejiang University
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Yu Jian-heng
Affiliated First Hospital Zhejiang University
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Gao Jian-qing
College Of Pharmaceutical Sciences Zhejiang University:graduate School Of Pharmaceutical Sciences Os
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Liang Wen-quan
College Of Pharmaceutical Sciences Zhejiang University
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Tabata Yasuhiko
Institute For Frontier Medical Sciences Kyoto University
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Tabata Yasuhiko
Department Of Oral And Maxillofacial Surgery The Nippon Dental University School Of Life Dentistry A
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute. For Frontier Medical Sciences Kyot
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Tabata Yasuhiko
Department Of Biomaterials Kyoto University
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Yamaki Takahiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Gao Jian-qing
Inst. Of Pharmaceutics Coll. Of Pharmaceutical Sciences Zhejiang Univ.
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