Preliminary Results of Magnetic Resonance Imaging-aided High-dose-rate Interstitial Brachytherapy for Recurrent Uterine Carcinoma after Curative Surgery

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概要

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• This report presents initial experience with imaging-aided high-dose-rate interstitial brachytherapy (HDR-ISBT) for post-operative recurrence of uterine carcinoma. Fourteen patients presenting with post-operative recurrence of uterine carcinoma (nine cervix and five corpus) between July 2005 and October 2008 were enrolled in this study (median follow-up: 37 months, range: 6–59 months). We implanted magnetic resonance imaging (MRI)-compatible plastic applicators using our own ambulatory technique. HDR-ISBT treatment consisted of twice-a-day irradiation of 6 Gy each with at least a six-hour interval to provide the total prescribed dose. Treatment was based on treatment planning-computed tomography with MRI as a reference. Seven patients were treated with a combination of ISBT (median 30 Gy/5 fractions; range: 27–33 Gy) and external beam radiation therapy (EBRT), and the other seven with brachytherapy only (median 54 Gy/9 fractions; range: 48–54 Gy), one of whom had previously received pelvic EBRT. The three-year estimates of local control and overall survival rates were 77.9% (95% confidence interval (CI): 55.8–100%) and 77.1% (95% CI: 54.2–100%), respectively. Two patients, who had received combined treatment with EBRT showed untoward reactions, including a grade 3 subileus and grade 2 constipation. Another patient, who had been treated with ISBT alone, developed grade 2 urinary constriction. Our imaging-aided HDR-ISBT for post-operative recurrence of uterine carcinoma was found to be practical with promising preliminary results.

• 2011-05-16

著者

• Yoshioka Yasuo

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive

• 吉田 佳世

  Department Of Molecular Genetics Graduate School Of Medicine Osaka City University

• YOSHIDA Ken

  Department of Medicine, Cardiovascular Division, Osaka Ekisaikai Hospital

• KOIZUMI Masahiko

  Department of Radiation Oncology, Osaka Medical Center

• Yoshioka Yasuo

  Department Of Radiation Oncology Osaka University Graduate School Of Medicine

• Yoshioka Yasuo

  大阪大学 医学系研究科放射線治療学

• Yoshida Ken

  Department Of Internal Medicine And Cardiology Osaka Ekisaikai Hospital

• ISOHASHI Fumiaki

  Dept. of Radiation Oncology, Osaka University Graduate School of Medicine

• Takenaka Tadashi

  Department of Electrical Engineering, Faculty of Science and Technology, Tokyo University of Science

• Isohashi Fumiaki

  Department Of Biochemistry Osaka Medical Center For Cancer And Cardiovascular Diseases

• Koizumi M

  Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka Jpn

• Yoshioka Yasuo

  Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine

• Konishi Koji

  Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine

• TANAKA Eiichi

  Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

• YAMAZAKI HIDEYA

  Department of Radiology, Toyonaka Municipal Hospital

• Yoshioka Yasuo

  Dept. Of Energy Science And Engineering Musashi Inst. Of Tech.

• Tanaka Eiichi

  Department Of Multidisciplinary Radiotherapy Osaka University Graduate School Of Medicine

• Kato Masahiro

  Div. Of Medical Physics Oncology Center Osaka University Hospital

• Tanaka Eiichi

  Department Of Mechanical Science And Engineering Nagoya University

• Koizumi Masahiko

  Department Of Electronics And Information Systems Faculty Of Systems Science And Technology Akita Pr

• Takenaka Tadashi

  Depart. Elect. Eng. Fac. Science And Technology Science University Of Tokyo

• Yamashiro Y

  Osaka Univ. Suita Jpn

• KOTSUMA Tadayuki

  Department of Radiology, National Hospital Organization Osaka National Hospital

• KONISHI Kouji

  Department of Radiation Oncology, Osaka University Graduate School of Medicine

• Yamazaki Hideya

  Department Of Radiology Kyoto Prefectural University Of Medicine

• Konishi Kouji

  Department Of Knowledge-based Information Engineering Toyohashi University Of Technology

• Isohashi Fumiaki

  Department Of Radiation Oncology Osaka University Graduate School Of Medicine

• Kotsuma Tadayuki

  Department Of Radiation Oncology Osaka University Graduate School Of Medicine

• Tanaka Eiichi

  Department Of Mechanical Engineering Nagoya Univeisity

• Kato Masahiro

  Department Of Radiation Oncology Osaka University Graduate School Of Medicine

• Takenaka Tadashi

  Department Of Radiation Oncology National Hospital Organization Osaka National Hospital

• Yoshida Ken

  Department Of Cardiology Kawasaki Medical School

• Tanaka Eiichi

  Department Of Electrical And Electronics Engineering Kobe University

• Tanaka Eiichi

  Department Of Applied Physics And Chemistry The University Of Electro-communications

• Yoshioka Yasuo

  Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University

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