The Utility of Poly(γ-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy
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概要
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Cytotoxic T-lymphocytes (CTLs) specific for tumor-associated antigens (TAAs) act in the immune surveillance system as major effector cells to eliminate malignant cells. Immunization with TAA-loaded dendritic cells (DCs) has great potential for treating cancer, because DCs are potent antigen-presenting cells capable of inducing antigen-specific CTLs by the primary activation of naive T-lymphocytes. The establishment of a non-cytotoxic and efficient antigen delivery method is required to improve the efficacy of DC-based cancer immunotherapy. We developed biodegradable poly(γ-glutamic acid) nanoparticles (γ-PGA NPs) that can efficiently entrap various proteins as antigen delivery carriers. γ-PGA NPs efficiently delivered entrapped antigenic proteins into DCs without cytotoxicity and presented antigens to DCs via major histocompatibility complex class I and II molecules. Immunization with TAA-loaded DCs using γ-PGA NPs inhibited tumor growth by inducing TAA-specific CTLs. These findings indicate that γ-PGA NPs can function as useful antigen delivery carriers in DC-based cancer immunotherapy.
著者
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Mukai Yohei
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Yoshioka Yasuo
Department Of Radiation Oncology Osaka University Graduate School Of Medicine
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Nakagawa Shinsaku
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Okada Naoki
Department Of Bioppharmaceutics Kyoto Pharmaceutical University
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Ishii Yumiko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Matsuo Kazuhiko
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Matsuo Keisuke
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Yoshinaga Tomoyo
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Akashi Mitsuru
The Center for Advanced Medical Engineering and Informatics, Osaka University
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Okada Naoki
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Ishii Yumiko
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Yoshinaga Tomoyo
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Yoshioka Yasuo
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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