Oral Candidiasis Deteriorated by Local Application of a Glucocorticoid-Containing Film in a Mouse Model(Biopharmacy)
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概要
- 論文の詳細を見る
In order to estimate predisposing activity of oral application of beclomethasone dipropionate (BDP)-containing mucoadhesive films for oral candidiasis, the effects of BDP on growth of Candida albicans were examined in vivo and in vitro. Murine neutrophils inhibited the mycelial growth of C. albicans in vitro, but this anti-Candida activity was clearly suppressed by the presence of 10^<-6>M of BDP. In vitro, a BDP-release test showed that the amount of BDP released from BDP-containing films into the fluid phase increased in a time- and concentration-dependent manner and reached about 10-15% of the total amount of BDP in the film within 30 min. When the BDP-containing film was attached to the tongues of mice orally infected with C. albicans, oral infection by C. albicans deteriorated, but not as severely as in mice systemically immunosuppressed with prednisolone. Based on these findings, we also discuss the problems associated with the clinical application of BDP-film as an anti-inflammatory tool.
- 公益社団法人日本薬学会の論文
- 2008-02-01
著者
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Abe Shuichi
山形県立新庄病院
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Abe S
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Abe Shigeru
Departments Of Radiology And Cardiology Yamagata Prefectural Shinjo Hospital
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Abe S
Teikyo Univ. Tokyo Jpn
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Abe Shigeru
Research Center For Medical Mycology Teikyo University School Of Medicine
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Abe S
Japan Poliomyelitis Res. Inst. Tokyo Jpn
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Abe Shigeru
Research Center For Medical Mycology Teikyo University
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YANAGI Mashiho
Division of Medical and Pharmaceutical Sciences-II, Faculty of Pharmaceutical Sciences, Teikyo Unive
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HISAJIMA Tatsuya
Research Center for Medical Mycology, Teikyo University
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ISHIBASHI Hiroko
Research Center for Medical Mycology, Teikyo University
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AMEMIYA Ayako
Division of Medical and Pharmaceutical Sciences-II, Faculty of Pharmaceutical Sciences, Teikyo Unive
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WATANABE Machiko
Division of Medical and Pharmaceutical Sciences-II, Faculty of Pharmaceutical Sciences, Teikyo Unive
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Amemiya Ayako
Division Of Medical And Pharmaceutical Sciences-ii Faculty Of Pharmaceutical Sciences Teikyo Univers
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Yanagi Mashiho
Division Of Medical And Pharmaceutical Sciences-ii Faculty Of Pharmaceutical Sciences Teikyo Univers
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Abe Shigeru
Teikyo University Institute Of Medical Mycology And Genome Research Center Teikyo University
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Ishibashi Hiroko
Research Center For Medical Mycology Teikyo University
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Watanabe Machiko
Division Of Medical And Pharmaceutical Sciences-ii Faculty Of Pharmaceutical Sciences Teikyo Univers
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Abe Sigeru
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Abe Shigeru
Teikyo University Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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