Therapeutic Effects on Murine Oral Candidiasis by Oral Administration of Cassia (Cinnamomum cassia) Preparation
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概要
- 論文の詳細を見る
We examined the effects of spices and herbs on Candida albicans growth using in vitro assay and therapeutic activity of some selected herbal preparations against murine oral candidiasis. All tested samples: lemongrass ( Cymbopogon citratus ) ,lemon balm ( Melissa officinalis ) ,thyme ( Thymus vulgaris ) ,rosemary ( Rosmarinus officinalis) ,roselle ( Hibiscus sabdariffa ) ,green tea ( Camellia sinensis ) ,and cassia ( Cinnamomum cassia ) inhibited Candida mycelial growth in vitro.The results of this assay showed that the anti- Candida activity of lemongrass, green tea, and cassia is stronger than that of the other tested herbs. Oral administration of lemongrass or green tea did not result in significant improvement in the murine oral candidiasis, while the administration of cassia improved the symptoms and reduced the number of viable Candida cells in the oral cavity. The results of in vitro Candida growth assay including GC/MS analysis suggested that cinnamaldehyde in the cassia preparation was the principal component responsible for the inhibitory activity of Candida mycelial growth. These findings suggest that oral intake of a cassia preparation is a clinical candidate for a prophylactic or therapeutic tool against oral Candida infection.
- 日本医真菌学会の論文
- 2010-01-30
著者
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山崎 幹夫
千葉大学薬学部
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Takeuchi T
Bioresource Laboratories Mercian Corp.
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Takeuchi T
Institute Of Microbial Chemistry
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Arai Ryo
Research And Development Division S&b Foods Inc.
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Abe S
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Abe Shigeru
Departments Of Radiology And Cardiology Yamagata Prefectural Shinjo Hospital
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Abe S
Teikyo Univ. Tokyo Jpn
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Yamazaki Masatoshi
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Yamaguchi Hideyo
Teikyo Univ. Inst. Of Medical Mycology Tokyo Jpn
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Yamaguchi Hideyo
Departments Of Microbiology And Immunology University Of Teikyo School Of Medicine
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TAKIZAWA Toshio
Teikyo University Institute of Medical Mycology
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ISHIBASHI Hiroko
Teikyo University Institute of Medical Mycology
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ABE Shigeru
Teikyo University Institute of Medical Mycology
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Takizawa Toshio
Teikyo Univ. Inst. Of Medical Mycology
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Takeuchi Toshio
Research And Development Department Kibun Food Chemifa Co. Ltd.
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Mimaki Yoshihiro
Lab. Of Medicinal Plant Sci. School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sci. Jpn
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Abe S
Japan Poliomyelitis Res. Inst. Tokyo Jpn
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INOUE Shigeharu
Teikyo University Research Institute of Medical Mycology
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Taguchi Yuuki
Research And Development Division S&b Foods Inc.
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Haraguchi Yuji
Department Of Hygiene And Virology Gunma University School Of Medicine
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Abe Shigeru
Teikyo University Institute Of Medical Mycology And Genome Research Center Teikyo University
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Inouye Shigeharu
Teikyo Univ. Inst. Of Medical Mycology
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Inouye S
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Ishibashi Hiroko
Research Center For Medical Mycology Teikyo University
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SAGAWA Takehito
Research and Product Development Division, S & B Foods Inc.
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Abe Sigeru
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Yamaguchi Hideyo
Teikyo University Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Arai Ryo
Research And Product Development Division S & B Foods Inc.
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Sagawa Takehito
Research And Product Development Division S & B Foods Inc.
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Abe Shigeru
Teikyo University Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Yamaguchi Hideyo
Teikyo Univ. Inst. Medical Mycology
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Takeuchi T
Inst. Microbial Chemistry Shinagawa‐ku Jpn
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SAGAWA Takehito
Research and Analysis Center, Research and Product Development Division, S&B FOODS Incorporated
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