Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp. (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro
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概要
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One new benzamide, 3-hydroxyl-2-N-iso-butyryl-anthranilamide (1), together with two known benzamides (2, 3) and three known quinazolines (4—6), was isolated from a mangrove actinomycetes Streptomyces sp. (No. 061316), which displayed inhibiting Caspase-3 activity in vitro. The structure of 1 was elucidated by electrospray ionization (ESI)-MS, NMR spectroscopies and X-ray crystal diffraction. After evaluation of all compounds for their inhibitory effect on Caspase-3 in vitro, 3-hydroxyl-anthranilamide (2) and 8-hydroxyl-2,4-dioxoquinazoline (6) showed activity against Caspase-3 with IC50 values of 32 and 36 μM, respectively.
著者
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Gao Hao
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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Wang Ying
Institute Of Animal Sciences Chinese Academy Of Agricultural Sciences (caas)
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Li Jia
National Center For Drug Screening State Key Laboratory Of Drug Research Shanghai Institute Of Mater
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Chen Ying
Institute Of Pharmacology Toxicology Academy Of Military Medical Sciences
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Chen Guodong
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy
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Tang Jinshan
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy
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Huang Yuanfan
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy
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Zhao Huinan
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy
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Lin Haipeng
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Science
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Xie Qingyi
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Science
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Hong Kui
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Science
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Yao Xinsheng
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy
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Chen Ying
Institute Of Medicinal Plant Development Chinese Academy Of Medical Sciences & Peking Union Medi
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Li Jia
National Center for Drug Screening/State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica
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Gao Hao
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Chen Guodong
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Zhao Huinan
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Yao Xinsheng
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Hong Kui
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Sciences
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Chen Ying
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Tang Jinshan
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Lin Haipeng
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Sciences
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Wang Ying
Institute of Traditional Chinese Medicine and Natural Products, Jinan University College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
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Xie Qingyi
Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Sciences
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