HLA and Clinical Manifestations in Takayasu Disease : SYMPOSIUM ON CLINICAL PROBLEMS IN AORTIC DISEASES
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概要
- 論文の詳細を見る
In previous studies on HLA antigens in patients with Takayasu disease, we found a statistically high frequency of haplotype Bw52-Dw12. Clinico-pathological conditions of this disease observed for 85 ± 3 months were compared between 29 patients with (positive group) and 39 patients without this haplotype (negative group), among 82 patients with Takayasu disease. Blood sedimentation rate and C-reactive protein exhibited statistically significant high figures in the positive group as compared with those in negative group, while no differences were seen in rheumatoid arthritis test, antistreptolysin-0 titer, anti-DNA antibody, levels of circulating immune complexes, platelet aggregation, although all revealed high levels in the positive group. Pulmonary disorders were more frequent in positive group. Fourteen patients (48%) in the positive group and 5 (13%) in the negative group had abnormalities in the aortic valve (p < 0.01). In 14 patients in the positive (38%) and 5 in the negative (13%) groups, the systolic blood pressure was over 140 mmHg (p < 0.01). Four patients in the positive (17%) and one in the negative groups (3%) were blind (p < 0.01). These data suggest that in patients with a haplotype of Bw52-Dw12, there is a greater likelihood of an active inflammatory state and a rapid progression of these morbid conditions.
- 社団法人日本循環器学会の論文
- 1982-02-20
著者
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OHTA Nobuo
Department of Otolaryngology, Yamagata University School of Medicine
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SASAZUKI Takehiko
Department of Genetics, Medical Institute of Bioregulation, Kyushu University
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Numano Fujie
The Their Department Of Internal Medicine Tokyo Medical And Dentao University
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Numano Fujio
Third Department Of Internal Medicine Tokyo Medical And Dental University
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Numano Fujio
Department Of Internal Medicne Tokyo Medical And Dental University.
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Ohta Nobuo
Department Of Human Gentics Tokyo Medical And Dental University
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NUMANO FUJIO
Depertment of Internal Medicine
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Sasazuki Takehiko
Department Of Gene Diagnostics And Therapeutics International Medical Center Of Japan
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Sasazuki Takehiko
Department Of Human Gentics Tokyo Medical And Dental University
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Ohta Nobuo
Department Of Ent School Of Medicine Yamagata University
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Numano Fujio
Department Of Internal Medicine (3) Tokyo Medical And Dental University
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