PLASMA LEVELS OF THROMBOXANE B_2 AND CYCLIC NUCLEOTIDES DURING EXERCISE TEST IN PATIENTS OF ISCHEMIC HEART DISEASE : Ischemic heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 1981-08-20
著者
-
Maruyama Yoshiaki
Department of Health Promotion, Saitama Medical Center, Saitama Medical University
-
Yamamoto Machiko
The Cardiovascular Institute
-
Nishiyama Kenji
The Third Department Of Internal Medicine Tokyo Medical & Dental University
-
Nishiyama Keiji
The Cardiovascular Institute
-
Kishi Yukio
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
-
Kishi Yukio
The Their D The Their Department Of Internal Medicine Tokyo Medical And Dentao University
-
Numano Fujio
The Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Numano Fujie
The Their Department Of Internal Medicine Tokyo Medical And Dentao University
-
Kishi Yukio
Center For Preventive Medicine Tokyo Kyosai Hospital
-
Numano Fujio
Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Numano Fujio
Department Of Internal Medicne Tokyo Medical And Dental University.
-
NISHIYAMA Keiji
The Third Department of Internal Medicine, Tokyo Medical and Dental University
-
YAJIMA Michiyoshi
The Third Department of Internal Medicine, Tokyo Medical and Dental University
-
Sekine Masaaki
The Third Department of Internal Medicine,Tokyo Medical and Dental University
-
Koyama Tadayoshi
The Third Department of Internal Medicine,Tokyo Medical and Dental University
-
TURKOGLU CUNEYT
ent of I The Their Department of Internal Medicine, Tokyo Medical and Dentao University
-
MAEZAWA HIDENORI
The Their Department of Internal Medicine, Tokyo Medical and Dentao University
-
Maezawa Hidenori
Third Department of Internal Medicine, Tokyo Medical and Dental University
-
Namba Ken-ichi
The Cardiovascular Institute
-
Numano Fujio
The Third Department Of Internal Medicine
-
Yajima Michiyoshi
The Third Department Of Internal Medicine Tokyo Medical & Dental University
-
Kishi Yukio
Department Of Cradiovascular Medicine Tokyo Medical And Dental University
-
Sekine Masaaki
The Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Hosaka Toshiaki
The Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Nishiyama Keiji
Department Of Internal Medicne Tokyo Medical And Dental University.
-
TURKOGLU Cuneyt
The Third Department of Internal Medicine, Tokyo Medical and Dental University
-
Turkoglu Cuneyt
Ent Of I The Their Department Of Internal Medicine Tokyo Medical And Dentao University
-
Hosoka Toshiaki
Department Of Internal Medicine (3) Tokyo Medical & Dental University
-
Maezawa Hidenori
Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Numano Fujio
Department Of Internal Medicine (3) Tokyo Medical And Dental University
-
Koyama Tadayoshi
The Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Numano Fujie
Department Of Internal Medicine (3) Tokyo Medical And Dental University
-
Maezawa Hidenori
The Third Department Of Internal Medicine Tokyo Medical And Dental University
-
Maezawa Hidenori
The Third Department Of Internal Medicine Tokyo Medical And Dental University School Of Medicine
-
Nishimura Kenji
The Cardiovascular Institute And Fukuda Denshi Co. Ltd
関連論文
- Quality of Wafarin Control Affects the Incidence of Stroke in Elderly Patients with Atrial Fibrillation
- THE EFFECT OF SHORT-TERM SUPERVISED TRAINING AFTER CORONARY ARTERY BYPASS GRAFT (CABG)
- AUTONOMIC NERVOUS ACTIVYTY DURING HEAD-UP TILT : A DEMONSTRATION OF SYMOPATHETIC NERVOUS ACTIVATION PRECEDING NEURALLY MEDIATED SYNCOPE
- -P107- ASSESSMENT OF THE CHARACTERISTICS OF TRANSIENT COLLATERAL CIRCULATION DURING SUDDEN VASOSPASTIC CORONARY OCCLUSION
- -378- COMPARISON BETWEEN LACTATE AT AND RESPIRATORY AT IN SPECIAL REFERENCE TO OXYGEN TRANSPORT
- -376- RESTING CARDIAC OUTPUT AND EXERCISE CAPACITY IN PATIENTS WITH IMPAIRED CARDIAC FUNCTION
- -54- COMPARISON OF VT DURING EXERCISE WITH THAT IN RECOVERY PERIOD : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PROGNOSIS OF VARIANT ANGINA WITH MEDICAL TREATMENT : Ischemic Heart Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DIFFERENCE IN EFFECTS OF PROPRANOLOL ON EXERCISE-INDUCED ST DEPRESSION IN THE PATIENTS WITH FALSE VS TRUE POSITIVE TREADMILL EXERCISE TEST : Excercise Test : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- CLINICAL SIGNIFICANCE AND HEMODYNAMIC DETERMINANTS OF ANAEROBIC THRESHOLD (AT) IN PATIENTS WITH CORONARY HEART DISEASE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
- COMPARATIVE EFFECTS OF ISOSORBIDE DINITRATE (ISDN), NIFEDIPINE (Nf) AND PROPRANOLOL (P) IN DIFFERENT TYPES OF EFFORT ANGINA : A STUDY BY TREADMILL EXERCISE TEST : Cardiovascular Drugs : 46th Annual Scientific Meeting, Japanese Circulation Society
- HEART RATE RESPONSE TO TREADMILL EXERCISE TESTING IN PATIENTS WITH SICK SINUS SYNDROME : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- HANDOGRIP-INDUCED NEGATIVE U WAVE IN HYPERTENSIVE SUBJECTS : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- 0997 CHANGES IN HEART RATE RESPONSE TO EXERCISE AND THE COEFFICIENT IN : KARVONEN'S FORMULA FOR AEROBIC EXERCISE TRAINING AFTER CORONARY BYPASS SURGERY
- FACTORS AFFECTING THE EXERICISE CAPACITY AFTER VALVE REPLACEMENT
- PE-473 Clinical 2-year Follow-up Results in Bifurcation Lesions with Sirolimus Eluting Stent and Bare Metal Stent(PE079,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Cir
- Effect of Angiotensin Converting Enzyme Inhibitors and β-Blockers on Left Ventricular Remodeling After Coronary Artery Bypass Graft Surgery
- Clinical Outcomes after Stenting with or without IVUS Guidance(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-125 Relation of ACE Inhibitor and β Blocker with Left Ventricular Remodeling in Patients after Coronary Artery Bypass Graft Surgery(Cardiovascular Surgery/CABG 1 (IHD) : OJ15)(Oral Presentation (Japanese))
- Immunocytochemical Analysis of the AtheroscLerotic lesion : 54th Annual Scientific Session of the Japanese Circulation Society
- -0860-CELLULAR COMPOSITION OF THE REPARATIVE TISSUE RESPONSE AT THE SITES OF PTCA : AN IMMUNOCYTOCHEMICAL ANALYSIS USING MONOCLONAL ANTIBODIES : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Immunocytochemical analysis of the site of percutaneous transluminal coronary angioplasty (PTCA).
- Genetic Vulnerability of Cortical Neurons Isolated from Stroke-Prone Spontaneously Hypertensive Rats in Hypoxia and Oxygen Reperfusion
- OJ-203 Systemic and Virtual Histological Determinant Factors of Coronary Distensibility(OJ34,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-338 Relationship between coronary artery distensibility and plaque composition determined by Virtual Histology-IVUS(Intravascular endoscopy/Intravascular ultrasound(06)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-005 Longitudinal Inhomogeneity of Coronary Distensibility in Acute Coronary Syndrome Related Plaques(Acute coronary syndrome, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-777 IVUS Reduces Restenosis Rate after Bare-Metal Stenting in Patients with Acute Myocardial Infarction(Intravascular endoscopy/Intravascular ultrasound-7 (I) PJ135,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PE-369 Parameters of Cardiac Dyssynchrony Predicts Chronic Cardiac Function after Acute Myocardial Infarction(Echo/Doppler-9 (I) PE62,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Real-time 3D Echo Cardiac Wall Motion Dyssyncrony Reflect Cardiac Function in Patients of Acute Myocardial Infarction(Echo/Doppler 1 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-071 Inhomogeneous Coronary Compliance Is Related to Plaque Vulnerability(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- Correlation of left ventricular dyssynchrony with myocardial stunning using dual single photon emission computed tomography of ^iodine-β-methyl iodophenyl pentadecanoic acid and ^thallium scintigraphy after reperfusion therapy
- CATECHOLAMINE RECEPTORS IN CULTURED BOVINE SMOOTH MUSCLE CELLS FROM CORONARY AND AORTIC TISSUES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- THE ROLE OF PROSTAGLANDINS ON THE PATHOPHYSIOLOGY OF VARIANT ANGINA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Ischemic Heart Disease (II)
- THE CHANGE IN THE EXERCISE CAPACITY AFTER VALVE REPLACEMENT
- USEFULNESS OF THE LOW WORK RATE SINGLE STAGE EXERCISE TESTING TO EVALUATE EXERCISE CAPACITY IN MODERATE TO SEVERE HERT FAILURE
- DOSE OF ASPIRIN AS ANTI-PLATELET DRUG : Surgery, Platelet and Thrombosis : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PJ-348 Impaired Dilator Response to Atrial Natriuretic Peptide of Coronary Resistance Vessel Precedes Endothelial Dysfunction in Hyperinsulinaemia(Coronary circulation, basic/clinical-5 (IHD) PJ59,Poster Session (Japanese),The 70th Anniversary Annual Scie
- Visceral Leishmaniasis Misdiagnosed as Malignant Lymphoma
- PROGESTERONE TREATMENT OF TAKAYASU'S DISEASE : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PULSED DOPPLER ECHOCARDIOGRAPHIC ASSESSMENT OF LV AND RV FILLING IN VASOSPASTIC ANGINA WITHOUT SIGNIFICANT CORONARY OBSTRUCTIVE LESIONS : Echocardiography (II) : FREE COMMUNICATIONS (IV) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE
- Accuracy of three-dimensional echocardiography in patients with prior anteroseptal myocardial infarction
- Clinical Characteristics and Coronary Flow Reserve in Smokers with Vasospastic Angina (Smoking 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants
- HLA-DR, MT AND MB ANTIGENS IN TAKAYASU DISEASE : Peripheral Circulation . Cerebral Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- HLA and Clinical Manifestations in Takayasu Disease : SYMPOSIUM ON CLINICAL PROBLEMS IN AORTIC DISEASES
- CONSTITUTIONAL FACTORS IN TAKAYASU DISEASE : FROM THE STUDY OF MULTIPLEX FAMILIES WITH TAKAYASU DISEASE : Arrhythmia I, Immunity & Heredity, Contractile Protein : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society
- TAKAYASU'S ARTERITIS. A FOLLOW-UP STUDY : Cardiomyopathy, Myocarditis : 53 Annual Scientific Meeting, Japanese Circulation Society
- -P254- CORONARY SMOOTH MUSCLE CELL DAMAGE BY ACTIVATED PLATELETS AND ITS PREVENTION
- BIOCHEMICAL STUDIES ON ALCOHOL INDUCED CORONARY SPASMS : Coronary Spasm : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CHANGES IN GLYCOLYTIC ENZYME ACTIVITIES AND CYCLIC NUCLEOTIDE LEVELS OF CULTURED BOVINE VASCULAR CELLS IN HYPERLIPIDEMIC MEDIA (Histo- and Cytochemistry in Tissue Culture)
- CHANGES IN THE PLASMA LEVELS OF THROMBOXANE B_2 AND CYCLIC NUCLEOTIDES IN PATIENTS WITH TAKAYASU DISEASE
- PLASMA THROMBOXANE B_2 LEVELS IN TAKAYASU DISEASE : Coagulation, Arteriosclerosis : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- HISTOENZYMATIC STUDY OF VESSEL WALL : Glycolytic enzyme activities in the arterial wall of man and various experimental animals and their changes at acute vascular injury or long term cholesterol feeding. : Proceedlngs of the 35th Annual Meetlng of the Ja
- Comparative Studies of Glycolytic Enzyme Activities in the Arterial wall of Man and Animals
- -170- ETIOLOGY OF AORTIC REGURGITATION IN TAKAYASU ARTERITIS : Myocardial Infarction, Valvular Heart Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CYCLIC NUCLEOTIDES RELEASE WITHIN THE CORONARY CIRCULATION RESPONSE TO ERGONOVINE MALEATE AND ISOSORBIDE DINITRATE : Coronary Circulation : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CLINICAL SIGNIFICANCE OF PTCA IN PATIENTS WITH VASOSPASTIC ANGINA : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PLASMA THROMBOXANE B_2, 6-KETO PGF_ AND CYCLIC NUCLEOTIDES LEVELS AS RELATED TO TREADMILL EXERCISE TEST IN PATIENTS WITH ISCHEMIC HEART DISEASE
- ARTERIOGRAPHIC FEATURES OF MYOCARDIAL INFARCTION AFTER ALCOHOL INGESTION : Ischemic Heart Disease (V) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- THE ANGIOGRAPHIC CHARACTERISTICS OF CORONARY SPASM : RELATION OF CORONARY SPASM TO SITES, SHAPES AND SEVERITY OF ORGANIC STENOSIS : Ischemic Heart Disease (V) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- QUANTITATIVE ASSESSMENT OF CINEANGIOGRAPHIC LEFT VENTRICULAR CONTRACTION WITH REGIONAL CURVATURE : Cardiac Function (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- INTRACORONARY PLATELET ACTIVATION DURING ERGONOVINE-INDUCED CORONARY SPASM : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- IDENTIFICATION OF MACROPHAGE-DERIVED CELLS IN ATHEROMATOUS LESIONS BY HYBRIDOMA MONOCLONAL MACROPHAGE ANTIBODY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Pathology Morphology
- ECHOCARDIOGRAPHIC ANALYSIS OF PROPRANOLOL EFFECTS ON MYOCARDIAL CONTRACTILITY AND LEFT VENTRICULAR FUNCTION IN NORMALS AND PATIENTS WITH ISCHEMIC HEART DISEASE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
- Histochemical Studies on ThromboxaneA_2-Induced Myocardial Infarction
- P-Selectin Expression, but not GPIIb/IIIa Activation, is Enhanced in the Inflammatory Stage of Takayasu's Arteritis(CLINICAL INVESTIGATION)
- PJ-446 Comparison of responses on coronary flow reserve in hyperinsulinemia and diabetes mellitus with angiographically normal coronary arteries(Diabetes/Obesity 3 (H) : PJ74)(Poster Session (Japanese))
- Opening of KATP Channel Attenuates the Increase in QT Dispersion Produced by the First Balloon Inflation During Coronary Angioplasty
- Ethanol Attenuates Cytokine-induced Endothelial Activation and Restores Anti-platelet Function of Human Endothelial Cells by Enhancing CD39 Expression
- Impaired Dilator Response to Atrial Natriuretic Peptide of Coronary Resistance Vessel in Hyperinsulinaemia with Angiographically Normal Coronary Arteries
- New Method of Estimating Myocardial Infarct Size Using Technetium-99m Pyrophosphate and Thallium-201 Dual Single Photon Emission Computed Tomography Imaging
- Long-Term Patency of an Aorta-Aortic Graft Bypass in a Patient with Takayasu Arteritis
- Platelet-Endothelium Interaction-A key Connection to Atherothrombotic Events
- P504 SENSITIVITY OF PLATELETS TO NITRIC OXIDE DECREASED AFTER EXERCISE IN NORMAL SUBJECTS
- 0779 PLATELETS ARE SUPERSENSITIVE TO NITRIC OXIDE AND PROSTACYCLIN IN ATHILETES
- -0817-EFFECTS OF ALCOHOL ON CYCLIC GMP METABOLISM IN CORONARY SMOOTH MUSCLE CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0609-ALTERATION OF ADENINE NUCLEOTIDE METABOLISM IN CORONARY SMOOTH MUSCLE CELLS BY ACTIVATED PLATELETS
- -213-SUPERSENSITIVITY OF PLATELETS TO LOWDOSE PROSTACYCLIN IN PATIENTS WITH ISCHEMIC HEART DISEASE : Ischemic Heart Disease I : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CORONARY ARTERIOGRAPHIC STUDY OF ANGINA PECTORIS WITH ST-SEGMENT ELEVATION BEFORE AND AFTER ERGOMETER EXERCISE (III) : Ichemic Heart Disease (II) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Sytotoxin Effect of Activated Platelets on Endothelial Cells
- -0370-ASSESSMENT OF CORONARY ARTERY LESIONS OR MYOCARDIAL PERFUSION ABNORMALITIES IN PATIENTS WITH TAKAYASU'S ARTERITIS USING THALLIUM-201 SCINTIGRAPHY
- Effects of Metabolic Syndrome on Cardiovascular Structure and Function in Hypertensive Patients
- Coronary Sapsm, Prostaglandin and HLA Factors : SYMPOSIUM ON PATHOGENESIS OF CORONARY ARTERY SPASM
- A Smooth Muscle Cell Specific Monoclonal Antibody in the Immunocytochemical Analysis of Atherosclerotic Lesions
- Immunohistochemical Studies on Annexin I and II in Takayasu Arteritis
- Dyssynchrony during acute phase determined by real-time three-dimensional echocardiography predicts reverse cardiac remodeling and improved cardiac function after reperfusion therapy
- EXPERIMENTAL STUDIES ON VEIN GRAFT ATHEROSCLEROSIS (I) HISTOCHEMICAL STUDIES USING MONOLONAL ANTIBODIES FOR SMOOTH MUSCLE CELLS AND MACROPHAGES
- Infiltration of β-Lipoprotein and Immunoglobulin-G into Aortic Wall of Rhesus Monkey (II)
- Microbiochemical Studies on Changes of Phosphofructokinase and Glucose-6-Phosphate Dehydrogenase Activity in Intima and Media of Aortic Wall of Rabbits in the Course of Cholesterol Feeding
- Histoenzymatic and Microbiochemical Analysis of Vessel Wall at Acute Vascular Changes
- Comparative Studies on Glycolytic Enzyme Activities in the Arterial Wall of Man : II
- Ulcerative Colitis, Takayasu Arteritis and HLA
- Multiple Endocrine Neoplasia Type 1 Associated with Spinal Ependymoma
- Histoenzymatic Analysis in the Aortic Wall of Rabbits at the Course of Cholesterol-Feeding and its Modefication by Estrogen or Pyridinol-carbamate Treatment
- PLASMA LEVELS OF THROMBOXANE B_2 AND CYCLIC NUCLEOTIDES DURING EXERCISE TEST IN PATIENTS OF ISCHEMIC HEART DISEASE : Ischemic heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Cholesterol Ester Hydrolase in Vessel Wall
- -1127-HUMAN INTERFERON GAMMA INHIBITS PROLIFERATION AND CHEMOTAXIS OF HUMAN VASCULAR SMOOTH MUSCLE CELLS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A-41 Immunohistochemical Studies On Annexin I, II In Takayasu Arteritis
- Relationships Between Waist Circumference, and Cardiac Volume and Function in Subjects of Health Screenings
- Left Ventricular Apical Aneurysm in Cardiac Sarcoidosis.