Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo
スポンサーリンク
概要
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Immunobiological roles of schistosome eggs during murine experimental infection were investigated with special reference to the induction of basophilic leukocytes. After single- or bisexual infection with Schistosoma mansoni in BALB⁄c mice, splenomegaly and liver granulomas were observed only in bisexual infection in parallel with deposition of mature parasite eggs. Comparison of the kinetics of basophil response revealed a marked increase in number in the bone marrow of mice with bisexual infection at the 7th week post infection as opposed to a marginal increase in single- sex infections. In the spleen, bimodal response was observed in the basophil responses; a small but repeatable peak at the 4th week after infection, increasing again at the 8th week, which corresponded to the initiation and maturation of parasite eggs in the affected organs of infected mice. The same time course was observed for IL-4 production by the splenocytes from mice of bisexual infection. To obtain more concrete evidence of the role of eggs in the induction of basophils, we tested using the intravenous egg injection model. Injection of eggs induced basophilia, and it was accompanied by the up-regulation of IL-4 production in splenocytes from the 8th day. Basophils induced in this model showed a high level of IL-4 production confirmed by flow cytometry, while faint levels of IL-4 production were observed for CD4+ T cells at this time point. In addition, we demonstrate that egg deposition is the trigger of basophil induction and activation in the murine experimental model of S. mansoni infection, which might play an essential role in the initiation of Th1⁄2 conversion during the course of S. mansoni infection in vivo.
- 2010-03-01
著者
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OHTA Nobuo
Department of Otolaryngology, Yamagata University School of Medicine
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ANYAN William
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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KUMAGAI Takashi
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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SHIMOGAWARA Rieko
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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SEKI Takenori
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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AKAO Nobuaki
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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OBATA Kazushige
Department of Immune Regulation Tokyo Medical and Dental University
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KWANSA-BENTUM Bethel
Department of Environmental Parasitology Tokyo Medical and Dental University Graduate School of Medi
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BOSOMPEM Kwabena
Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana
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BOAKYE Daniel
Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana
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WILSON Michael
Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana
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KARASUYAMA Hajime
Department of Immune Regulation Tokyo Medical and Dental University
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Ohta Nobuo
Department Of Environmental Parasitology Tokyo Medical And Dental University Graduate School Of Medi
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Boakye Daniel
Department Of Parasitology Noguchi Memorial Institute For Medical Research University Of Ghana
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Karasuyama Hajime
Department Of Immune Regulation Graduate School Tokyo Medical And Dental University
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Bosompem Kwabena
Department Of Parasitology Noguchi Memorial Institute For Medical Research University Of Ghana
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Wilson Michael
Department Of Parasitology Noguchi Memorial Institute For Medical Research University Of Ghana
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Wilson Michael
Department Of Ecology Evolution And Behavior University Of Minnesota
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Ohta Nobuo
Department Of Ent School Of Medicine Yamagata University
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Kumagai Takashi
Department Of Communications And Computer Engineering Graduate School Of Informatics Kyoto Universit
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Wilson Michael
Department Of Cardiothoracic Surgery Royal Prince Alfred Hospital The University Of Sydney
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