IgA Production and Tonsillar Focal Infection in IgA Nephropathy
スポンサーリンク
概要
- 論文の詳細を見る
IgA nephropathy (IgAN), the common primary glomerulonephritis, is a tonsillar focal infection characterized by the qualitative abnormality of IgA in circulation and IgA deposition in the renal mesangium. Mesangial deposition of IgA, which is composed predominantly of poorly galactosylated polymeric IgA1 (pIgA1), seems to be the initiating event in the pathogenesis of IgAN. The origin of poorly galactosylated IgA, however, remains unclear. Recent studies suggest that the mesangial polymeric IgA1 deposition could be derived from mucosally primed plasma cells. B cells may undergo IgA class switching to acquire the expression of IgA via T-cell-dependent or T-cell-independent pathways in mucosa-associated lymphoid tissue and then differentiate to IgA plasma cells or home in on systemic sites. Dendritic cells, including plasmacytoid dendritic cells and another type of antigen-retaining cell, follicular dendritic cells, have an irreplaceable role in IgA class-switch mechanisms by producing IgA-inducing signals. Furthermore, an increased number of pIgA1-secreting plasma cells in the bone marrow and tonsil, as well as increased IgA class switching, have been found in IgAN, providing a link between the mucosal immunity and IgAN. The favorable effect of tonsillectomy on patients with IgAN showed that tonsillar focal infection may be closely related to pIgA1 deposition in glomerular mesangium of patients with IgAN and at least a part of pIgA1 may originate from affected tonsils. Therefore, the indication for tonsillectomy should be considered in patients with IgA nephropathy, especially at a mild or early stage, to prevent future renal deterioration. In this paper, we focus on IgA class switching and the role of tonsils with focal infection in IgAN. [<I>J Clin Exp Hematopathol 52(3</I><I>) </I>: <I>161-170, 2012</I>]
著者
-
Kakehata Seiji
Department Of Otolaryngology Hirosaki University School Of Medicine
-
Yamakawa Mitsunori
Department Of Pathology Faculty Of Medicine Yamagata University
-
Ishida Akihiro
Department Of Applied Physics The National Defense Academy
-
Ohta Nobuo
Department Of Ent School Of Medicine Yamagata University
-
Ishida Akihiro
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
-
Meng Hongxue
Department of Pathological Diagnostics Faculty of Medicine, Yamagata University
-
Ohtake Hiroya
Department of Pathological Diagnostics Faculty of Medicine, Yamagata University
-
Yamakawa Mitsunori
Department of Pathological Diagnostics Faculty of Medicine, Yamagata University
-
Ohta Nobuo
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
関連論文
- A Peculiar Case of Acute Myeloid Leukemia Mimicking Plasmacytoid Dendritic Precursor Cell Leukemia
- Serum Concentrations of Eosinophil Cationic Protein and Eosinophils of Patients with Kimura's Disease
- Elevation of the Soluble form GPI-80, a β_2 Integrin-associated Glycosylphosphatidylinositol Anchored Protein, in the Serum of Patients with Wegener's Granulomatosis
- Th1, Th2, Tc1 and Tc2 cells of patients with otolaryngological diseases
- Analysis of the Comorbidity of Bronchial Asthma and Allergic Rhinitis by Questionnaire in 10,009 Patients
- Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo
- Seebeck Coefficient of Ultrathin Silicon-on-Insulator Layers
- Secondary Malignant Fibrous Histiocytoma Following Refractory Langerhans Cell Histiocytosis
- Magnetocrystalline Anisotropy and Crystal Fields in the Weak-Ferromagnet Ce_4Ni_3Pb_4(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Giant Uniaxial Anisotropy in the Magnetic and Transport Properties of CePd_5Al_2(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Red Electroluminescent Devices Using Mn-Doped CdS(Se)- and CdTe-ZnS Superlattices
- ZnS:Mn Electroluminescent Films Prepared by Hot Wall Technique
- An Indication of Quantum Hall Effect in PbTe-Pb_Sn_xTe Superlattice
- Enhanced UV♀1 tumor growth in CBF1 mice infected with Schistosoma mansoni due to modulation of Th1-like responses
- Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice
- Current status of tissue engineering for cardiovascular structures
- Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol
- Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone
- Overproduction of highly active trypanosome alternative oxidase in Escherichia coli heme-deficient mutant
- The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice
- Strain-specific difference in amino acid sequences of trypanosome alternative oxidase
- Leishmanicidal Effect of Curcumin in Vitro
- Trypanocidal Effects of Curcumin in Vitro
- Formation of Reactive Oxygen Intermediates Might be Involved in the Trypanocidal Activity of Gallic Acid
- Oral and Intraperitoneal treatment of Trypanosoma brucei brucei with a combination of ascofuranone and glycerol in mice
- Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
- Femtosecond Real-Time Pump-Probe Imaging Spectroscopy Implemented on a Single Shot Basis
- PbTe/PbS multilayer mirror for EuTe/PbTe surface emitting quantum cascade lasers (特集 赤外線技術とその応用)
- Growth of AIN/GaN superlattices for intersubband device application
- AlN/GaN Near-Infrared Quantum-Cascade Structures with Resonant-Tunneling Injectors Utilizing Polarization Fields : Semiconductors
- Quantum-Cascade Structure in AlN/GaN System Assisted by Piezo-Electric Effect : Semiconductors
- PbCaTe Films and PbCaTe/PbTe Superlattices Prepared by Hot-Wall Epitaxy
- Characteristics of Chlorine-Doped ZnSe Films and ZnSe-ZnS Superlattices Grown by Hot Wall Epitaxy
- Characteristics of Nitrogen-Doped ZnTe Films and ZnTe-ZnSe Superlattices Grown by Hot Wall Epitaxy
- A Study of Pre-Breakdown in Ultra-Thin Silicon Dioxide Films Using Carrier Separation Measurement
- A Simple Screening Method for Detecting Bindings between Oligopeptides and HLA-DR Molecules on Filter Papers:Possible Application for Mapping of Putative Helper T-Cell Epitopes on MSP1 of Plasmodium falciparum
- MSP1-reactive T cells in individuals in malaria endemic Solomon area and in non-immune Japanese
- Effects of streptococcal preparation, OK-432, on human peripheral neutrophil functions
- HLA-DR, MT AND MB ANTIGENS IN TAKAYASU DISEASE : Peripheral Circulation . Cerebral Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- HLA and Clinical Manifestations in Takayasu Disease : SYMPOSIUM ON CLINICAL PROBLEMS IN AORTIC DISEASES
- CONSTITUTIONAL FACTORS IN TAKAYASU DISEASE : FROM THE STUDY OF MULTIPLEX FAMILIES WITH TAKAYASU DISEASE : Arrhythmia I, Immunity & Heredity, Contractile Protein : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society
- A Case of Leiomyosarcoma of the Sphenoid Sinus
- Myocardial ^Tc-Sestamibi Washout in Patients with Dilated Cardiomyopathy : Comparisons with Endomyocardial Biopsy
- Research on calpain of Schistosoma japonicum as a vaccine candidate
- Adult worms of the rodent intestinal nematode, Strongyloides venezuelensis, successfully invatde chick intestinal mucosa
- Cloning and molecuar characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistoma japonicum
- Immune responses ageinst protozoal and nematodal infection in mice with underlyng Schistosoma mansoni infection
- Protective Effect of Vaccination with Toxoplasma Lysate Antigen and CpG as an Adjuvant against Toxoplasma gondii in Susceptible C57BL/6 Mice
- Screening of HLA-DR-Restricted Helper T-cell Epitopes of MSP1 of Plasmodium falciparum in Humans(Abstracts from the Malaria Workshop)
- Changes in AlPase Activity of Rabbit Articular Cartilages Associated with Aging and Joint Contracture
- Historical view of schistosomiasis japonica in Japan : implementation and evaluation of disease-control strategies in Yamanashi Prefecture
- Changes in HRP penetration into the articular cartilage of the experimentally contracted joint.
- In Situ Observation of Germinal Center Cell Apoptosis During a Secondary Immune Response
- Analysis of Infrared Photoacoustic Wave Form Detected by Piezoelectric Transducer : Photoacoustic Spectroscopy and Ultrasonic Microscopy
- Relationship between Airborne Cry j 1 and the Onset Time of the Symptoms of Japanese Cedar Pollinosis Patients
- Primary histiocytic sarcoma of the spleen associated with hemophagocytosis
- Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel
- Seebeck Effects and Electronic Thermal Conductivity of IV-VI Materials
- Dendritic cell and effector cell infiltration in soft tissue sarcomas with reactive lymphoid hyperplasia
- Fine binding Specificities to Ascaris suum and Ascaris lumbricoides antigens of the sera from patients of probable visceral larva migrans due to Ascaris suum
- Cerebrovascular Disease in Acute Leukemia : A Clinicopathological Study of 14 Patients
- MALIGNANT LYMPHOMA IN THE FEMALE URETHRA
- Differential Kinetic Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeutic Implications
- Role of lipids in electromotility of outer hair cells
- Two Cases of Plunging Ranula Managed by the Intraoral Approach
- The direct effects of cholesterol on outer hair cell motility
- Effect of SRT and the natural history of vestibular schwannoma
- Symposium introductory remarks : 'centenary symposium to celebrate the discovery of Schistosoma japonicum'
- Strong Intersubband Absorption in EuTe/PbTe Double-Well Superlattices at Normal Incidence
- IgA Production and Tonsillar Focal Infection in IgA Nephropathy
- Growth of Pillarlike GaN Nanostructures
- Design and Preparation of AlN/GaN Quantum Wells for Quantum Cascade Laser Applications
- Interdigitating Dendritic Cell Sarcoma and Follicular Dendritic Cell Sarcoma : Histopathological Findings for Differential Diagnosis
- Contrast-enhanced magnetic resonance imaging of malignant granular cell tumor with pathological correlation : a case report
- Interdigitating Cell Sarcoma-A report of an autopsy case and literature review-:—A report of an autopsy case and literature review—
- IgA Production and Tonsillar Focal Infection in IgA Nephropathy