Cerebrovascular Disease in Acute Leukemia : A Clinicopathological Study of 14 Patients

スポンサーリンク

概要

• 論文の詳細を見る

• Objective Cerebrovascular disease (CVD) is a serious complication of acute leukemia, and the underlying conditions are different from the common risk factors for CVD. The aim of this study was to characterize the clinical and pathological features of CVD in patients with acute leukemia. Patients or Materials In our series of 116 autopsied cases of acute leukemia during the period between January 1978 and December 1998, we had 14 patients who had CVD during the course of acute leukemia. The neuropathological and clinical features of those patients were examined. Results Neuropathological examination showed hemorrhagic infarction due to disseminated aspergillosis or mucormycosis (5 cases), multiple hemorrhages due to leukemic cell infiltration (2 cases) and a single massive hemorrhage with petechial hemorrhages in various regions of the brain (4 cases). Three patients had CVD due to miscellaneous causes. Clinicopathological correlation revealed that fungal disseminations occurred under agranulocytosis, while leukemic cell infiltration occurred under a marked leukocyotosis (peripheral white blood cell count >100, 000/μl). Four patients with coagulopathy, including three with disseminated intravascular coagulation (DIC) had a single massive hemorrhage. Conclusion Our study demonstrated that there were at least three types of CVD with specific Clinicopathological features. Hemorrhagic infarction under agranulocyotosis was due to disseminated aspergillosis or mucormycosis. Multiple cerebral hemorrhages under marked leukocyotosis was due to leukemic cell infiltration into the brain. Massive cerebral hemorrhage was associated with coagulopathy including DIC. (Internal Medicine 41:1130-1134, 2002)

• 社団法人 日本内科学会の論文
• 2002-12-01

著者

• YAMAKAWA Mitsunori

  Department of Pathology, Yamagata University School of Medicine

• Kitahara Tatsuro

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Kitahara Tatsuro

  山形大学 医学部循環･呼吸･腎臓内科学

• Tasaki Katsunari

  Department Of Hygiene & Preventive Medicine School Of Medicine Yamagata University

• KATO TAKEO

  Third Department of Internal Medicine, Yamagata University School of Medicine

• KAWANAMI Toru

  Third Department of Intenal Medicine, Yamagata University School of Medicine

• KURITA Keiji

  Third Department of Intenal Medicine, Yamagata University School of Medicine

• OMOTO Eijiro

  Third Department of Intenal Medicine, Yamagata University School of Medicine

• Omoto Eijiro

  Third Department Of Intenal Medicine Yamagata University School Of Medicine

• Yamakawa Mitsunori

  Department Of Pathology Faculty Of Medicine Yamagata University

• Kurita Keiji

  Departments Of Neurology Hematology Metabolism Endocrinology And Diabetology Faculty Of Medicine Yam

• Kawanami Toru

  Departments Of Neurology Hematology Metabolism Endocrinology And Diabetology Faculty Of Medicine Yam

• Konta Tsuneo

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Kato Takeo

  Third Department Of Internal Medicine Yamagata University School Of Medicine

• Yamakawa Mitsunori

  Department of Pathological Diagnostics Faculty of Medicine, Yamagata University

関連論文

• A Peculiar Case of Acute Myeloid Leukemia Mimicking Plasmacytoid Dendritic Precursor Cell Leukemia
• Clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease
• Effect of Renin-Angiotensin-Aldosterone System Triple Blockade on Non-Diabetic Renal Disease : Addition of an Aldosterone Blocker, Spironolactone, to Combination Treatment with an Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker
• Prevalence of human polyoma virus (BK virus and JC virus) infection in patients with chronic renal disease
• Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity
• PJ-479 Diacilglycerol kinase ζ inhibits myocardial atrophy and systolic dysfunction in streptozotocin-induced diabetes mellitus(Diabetes/Obesity/Metabolic syndrome(12)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulat
• Diacylglycerol Kinase ζ Rescues Gαq-Induced Heart Failure in Transgenic Mice
• Persistently Increased Serum Concentration of Heart-Type Fatty Acid-Binding Protein Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure
• Serum Carboxy-Terminal Telopeptide of Type I Collagen (ICTP) Predicts Cardiac Events in Chronic Heart Failure Patients With Preserved Left Ventricular Systolic Function
• PJ-493 Serial Measurements of Heart-Type Fatty Acid-Binding Protein (H-FABP) Levels for Predicting Cardiac Events in Chronic Heart Failure (CHF) Patients(Heart failure, clinical-13, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-322 Diacylglycerol Kinase-ε Prevents Cardiac Hypertrophy Induced by Continuous Administration of Phenylephrine : A New Specific Regulator of Gq α Signaling Cascade(Cardiac hypertrophy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanes
• PJ-174 Heart-Type Fatty Acid Binding Protein can Predict Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-9, The 71st Annual Scientific Meeting of the Japanese Circulation
• Diacylglycerol KinaseζAttenuates Pressure Overload-Induced Cardiac Hypertrophy
• OJ-073 Serum Carboxy-Terminal Telopeptide of Type I Collagen (ICTP) Predicts Cardiac Events in Patients with Diastolic Heart Failure(Heart failure, clinical-3 (M) OJ13,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
• Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure
• Combination of conventional biomarkers for risk stratification in chronic heart failure
• Factors correlated with plasma renin activity in general Japanese population
• PJ-779 8-Hydroxy-2'-Deoxyguanosine Predicts Adverse Clinical Outcomes in Patients with Heart Failure(PJ131,Heart Failure (Laboratory/Biomarkers) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-645 Risk Stratification by Combination of Serum Neopterin and TNF α in Patients with Heart Failure(PJ108,Heart Failure (Laboratory/Biomarkers) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers : Implications of BNP, H-FABP, and PTX3
• Relationship between antinuclear antibody and microalbuminuria in the general population : the Takahata study
• PJ-585 Heart-type Fatty Acid-binding Protein Levels Predict the Occurrence of Appropriate Implantable Cardioverter Defibrillator Therapy for Ventricular Tachycardia/Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(10)(A),Poster Session(Japanese),The
• PJ-524 Atrial Endothelial Impairment Induced by Innate Immune may cause Atrial Thrombosis(Infection/Inflammation/Immunity(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-309 Diacylglycerol Kinase-ζ Rescues G α q-induced heart failure in transgenic mice(Heart failure, basic(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-130 Multiple Biomarkers for the Prediction of Cardiac Events in Chronic Heart Failure (CHF) Patients(Heart failure, clinical(14)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-065 High Serum Level of Neopterin is a Risk Factor of Patients with Heart Failure(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-492 Heart-Type Fatty Acod-Binding Protein (H-FABP) and Brain Natriuretic Peptide (BNP) Levels in Japanese General Population : Effects of Physiological Characteristics(Heart failure, clinical-13, The 71st Annual Scientific Meeting of the Japanese Circu
• PJ-187 Pentraxin 3, a New Marker for Vascular Inflammation, is Increased in Patients with Unstable Angina Pectoris(Angina pectoris, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Mouse uroguanylin is localized in the kidney outer medulla and regulated by dehydration
• Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits
• Chronic Hypertriglyceridemia In Watanabe Heritable Hyperlipidemic Rabbits (a model for familial combined hyperlipidaemia) Accerelates Endothelial and Medial Smooth Muscle Dysfunctions
• Secondary Malignant Fibrous Histiocytoma Following Refractory Langerhans Cell Histiocytosis
• Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population : the Takahata study
• Dynamic ^I-MIBG SPECT reflects sympathetic nervous integrity and predicts clinical outcome in patients with chronic heart failure
• PJ-492 Cardiac 123I-MIBG Imaging can Classify Diastolic Heart Failure Patients(PJ083,Nuclear Cardiology (Coronary, Myocardium) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-218 Dynamic Technetium-99m-Sestamibi SPECT Predicts Cardiac Function in Chronic Phase in Patients with Acute Myocardial Infarction (AMI)(PJ037,Nuclear Cardiology (Coronary, Myocardium) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
• PJ-104 Serum Midkine Predicts Cardiac Events in Chronic Heart Failure Patients(Growth factor/Cytokine(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-051 Diacylglycerol Kinase-ε Restores Cardiac Dysfunction under Chronic Pressure Overload : A New Specific Regulator of G α q Signaling Cascade(Cardiac hypertrophy, basic/clinical(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
• PE-540 Pentraxin 3 (PTX3) Predicts Adverse Clinical Outcomes in Heart Failure Patients with Preserved Left Ventricular Systolic Function (LVSF)(Heart failure, clinical(12)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circu
• OJ-139 Multiple Biomarkers Approach for Risk Stratification in Heart Failure Patients(Heart failure, clinical(05)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-266 Diacylglycerol Kinase α Exacerbates Cardiac Injury after Ischemia/reperfusion in Transgenic Mouse Hearts(Acute myocardial infarction, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-062 Soluble Receptor for Advanced Glycation End Products is a Prognostic Factor for Heart Failure(Prognostic Biomarkers of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Circulating Levels of Heart-Type Fatty Acid-Binding Protein in a General Japanese Population : Effects of Age, Gender and Physiologic Characteristics
• Clinical utility of trace proteinuria for microalbuminuria screening in the general population
• Genetic Association between Aldehyde Dehydrogenase 2 (ALDH2) Variation and High-Density Lipoprotein Cholesterol (HDL-C) Among Non-Drinkers in Two Large Population Samples in Japan
• Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations
• A Palatinose-Based Balanced Formula Improves Glucose Tolerance, Serum Free Fatty Acid Levels and Body Fat Composition
• A Proposal for the Cutoff Point of Waist Circumference for the Diagnosis of Metabolic Syndrome in the Japanese Population(Letter to the Editor)
• Progression of Diabetic Nephropathy Enhances the Plasma Osteopontin Level in Type 2 Diabetic Patients
• An Unusual Case of Hypertensive Encephalopathy Involving the Brain Stem
• Clinical Utility and Approach to Estimate Postprandial Hypertriglycemia by A Newly Designed Oral Fat-loading Test
• Mechanism of an Inhibitory Effect of Nipradilol on Rat Vascular Smooth Muscle Cell Growth
• The D Allele of the Angiotensin-Converting Enzyme Insertion/Deletion (I/D) Polymorphism is a Risk Factor for Type 2 Diabetes in a Population-Based Japanese Sample
• The Long, but not the Short, Presequence of Human Coproporphyrinogen Oxidase is Essential for Its Import and Sorting to Mitochondria
• Increased Urinary Levels of Pentosidine, Pyrraline and Acrolein Adduct in Type 2 Diabetes.
• Cerebrovascular Disease in Acute Leukemia : A Clinicopathological Study of 14 Patients
• Type 2 Diabetes is Not a Risk Factor for Asymptomatic Ischemic Brain Lesion-The Funagata Study
• Platelet-Derived Growth Factor BB-Induced p38 Mitogen-Activated Protein Kinase Activation Causes Cell Growth, but not Apoptosis, in Vascular Smooth Muscle Cells
• Fibrillary Glomerulonephritis with Hypocomplementemia
• The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study
• An angiotensin II type-I receptor blocker, olmesartan medoxomil, attenuates lipid peroxidation in renal injury induced by subtotal nephrectomy
• Renal Cholesterol Embolic Disease Effectively Treated with Steroid Pulse Therapy
• Protein Kinase C (PKC) and Extracellular-Signal Regulated Kinase (ERK) Are Involved in Cardiac Hypertrophy of Rat Chronic Renal Failure Model
• Current status of tissue engineering for cardiovascular structures
• OE-241 Cardiac-specific Overexpression of Diacylglycerol Kinase ζPrevents Phenylephrine-induced Cardiac Hypertrophy in Transgenic Mice(Cardiac hypertrophy, basic/clinical-1 (M) OE41,Oral Presentation (English),The 70th Anniversary Annual Scientific Meetin
• OE-079 Cardiac-Specific Overexpression of Diacylglycelol Kinase ζ Attenuated Left Ventricular Remodeling and Improved Survival after Myocardial Infarction(Acute myocardial infarction, basic-1 (IHD) OE14,Oral Presentation (English),The 70th Anniversary Ann
• Pontine and extrapontine myelinolysis in a patient with acute lymphocytic leukemia who had hypernatremia before the onset of neurological symptomes
• Thiazolidinediones Exert Different Effects on Insulin Resistance between Dexamethasone-Theated Rats and Wistar Fatty Rats
• Sequential Changes in CGRP-like Immunoreactivity in NIDDM Model Otsuka Long-Evans Tokushima Fatty (OLETF) Rat Pancreatic Islets
• Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-β produced by tubular epithelial cells in response to high glucose
• Myocardial ^Tc-Sestamibi Washout in Patients with Dilated Cardiomyopathy : Comparisons with Endomyocardial Biopsy
• A novel mutation of coproporphyrinogen oxidase (CPO) gene in a Japanese family
• A novel autoantibody in paraneoplastic sensory-dominant neuropathy
• Binding of IDPN (β, β' -iminodipropionitrile) to rat spinal cord: Possible implication in the mechanism of spheroid formation in amyotrophic lateral sclerosis)
• Hereditary ceruloplasmin deficiency: A cerebro-retino-diabetic disease
• Ultrastructural localization of heparan sulfate-like immunoreactivity in spinal spheroids of motor neuron disease
• Hereditary Ceruloplasmin Deficiency - A New Type of Diabetes Mellitus
• FRS-102 Serum Soluble Receptor for Advanced Glycation End Product Level is Decreased in Acute Coronary Syndrome(Biomarker of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-033 Pentraxin 3, a New Marker for Vascular Inflammation, Predicts Adverse Clinical Outcomes in Patients with Heart Failure(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Anti-GBM glomerulonephritis in mice lacking IL-1β-converting enzyme (ICE)
• In Situ Observation of Germinal Center Cell Apoptosis During a Secondary Immune Response
• Prevalence of chronic kidney disease in the Japanese general population
• High variability of albuminuria in nondiabetic population : the Takahata Study
• A Novel Mutation of the Ceruloplasmin Gene in a Patient with Heteroallelic Ceruloplasmin Gene Mutation (HypoCPGM)
• Increase in Serum Ceruloplasmin with Aging is not Observed in Type 2 Diabetes
• Primary histiocytic sarcoma of the spleen associated with hemophagocytosis
• Dendritic cell and effector cell infiltration in soft tissue sarcomas with reactive lymphoid hyperplasia
• Cerebrovascular Disease in Acute Leukemia : A Clinicopathological Study of 14 Patients
• MALIGNANT LYMPHOMA IN THE FEMALE URETHRA
• T-Cell Lymphoma Showing a Non-Enhancing Diffuse White Matter Lesion with Marked Brain Atrophy
• The association between renal tubular damage and rapid renal deterioration in the Japanese population : the Takahata study
• An autopsy-proven case of myeloperoxidase-antineutrophil cytoplasmic antibody-positive polyarteritis nodosa with acute renal failure and alveolar hemorrhage
• Assessment of plasma glucose cutoff values to predict the development of type 2 diabetes in a Japanese sample : the Funagata Study
• Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population
• Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease : analysis of data from a nationwide health checkup
• Relationship between dietary intake and microalbuminuria : findings from the Takahata study
• Risk factor profiles based on estimated glomerular filtration rate and dipstick proteinuria among participants of the Specific Health Check and Guidance System in Japan 2008
• Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy
• The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population : the Takahata study
• Reversible Distension of the Subarachnoid Space around the Optic Nerves in a Case of Idiopathic Hypertrophic Pachymeningitis

もっと見る 閉じる

スポンサーリンク