Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model.
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概要
- 論文の詳細を見る
We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.
- 公益社団法人 日本薬理学会の論文
著者
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Iwata Hisashi
Department Of General And Cardiothoracic Surgery Graduate School Of Medicine Gifu University
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Yotsuyanagi Toshihisa
Faculty Of Pharmaceutical Science Nagoya City University
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OSADA Takashi
Department of Computer and Information Science, Graduate School of Engineering, Iwate University
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NABESHIMA Toshitaka
Department of Hospital Pharmacy, Nagoya University School of Medicine
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Yamamura Keiko
Department of Clinical Pharmacy, School of Pharmacy, Aichi Gakuin University
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Osada Takashi
Department of Hospital Pharmacy, Nagoya University School of Medicine
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