Effects of Dietary Vegetable Oils on Behavior and Drug Responses in Mice
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概要
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Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low α-linolenate/linoleate ratio and perilla oil with a high α-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils-for a relatively short period : 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The α-linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage : the activity decreased in the order of safflower, the mixture (1 : 1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the α-linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the α-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.
- 社団法人日本薬学会の論文
- 1996-03-15
著者
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OKUYAMA Harumi
Department of Preventive Nutraceutical Sciences, Nagoya City University, Graduate School of Pharmace
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YAMADA Kiyofumi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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OKUYAMA Harumi
Open Research Center for Lipid Nutrition, Kinjo Gakuin University College of Pharmacy
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Okuyama H
Nagoya City Univ. Nagoya Jpn
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Science Nagoya City University
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Huang Min-zhao
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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OHHARA Tatsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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NAITO Yukio
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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NAKASHIMA Yumiko
Graduate School of Pharmaceutical Sciences, Osaka University
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Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Nakashima Yoshie
Shimonoseki City Central Hospital Department Of Pediatrics
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Yamada Kiyomi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Naito Y
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Ohhara Tatsuo
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
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Nakashima Y
Shimonoseki City Central Hospital Department Of Pediatrics
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Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Watanabe Shiro
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University
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