A High Linoleate and a High α-Linolenate Diet Induced Changes in Learning Behavior of Rats. Effects of a Shift in Diets and Reversal of Training Stimuli
スポンサーリンク
概要
- 論文の詳細を見る
Rats fed from weaning on semi-purified diets supplemented either with linoleate-rich safflower oil (S) or α-linolenate-rich perilla oil (P) were mated. Half of the progeny were weaned to the original diet of the dams (SS and PP), the other two groups were shifted to diets enriched in the other fatty acid (SP and PS). Brightness-discrimination learning ability was tested daily for 30 d beginning at 11 weels of age, with a bright light as the positive stimulus. The learning performance was inferior in the group fed the safflower diet through two generations (SS) as compared with groups fed the perilla diet through two generations (PP) or for which the diets were shifted at weaning (PS and SP). The docosahexaenoate content of brain phospholipids was significantly less in the SS group compared with the three other groups. After 30 d of the learning test, the effect of shifting the stimulus was tested for another 30 d, this time using a dim light as the positive stimulus. The learning performance was superior in the PP group to the SS group throughout the latter 30 sessions, the difference being even more obvious than during the first 30 d. These results indicate that the decrease in the discrimination-learning ability induced by α-linolenate deficiency is a relatively reversible process; both the docosahexaenoate content in brain and the learning performance were restored by supplementing α-linolenate after the weaning.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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OKUYAMA Harumi
Open Research Center for Lipid Nutrition, Kinjo Gakuin University College of Pharmacy
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Yoshizumi S
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
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Yasuda S
Kanazawa Univ. Kanazawa Jpn
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Yasuda Shingo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Okuyama H
Nagoya City Univ. Nagoya Jpn
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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NAKASHIMA Yumiko
Graduate School of Pharmaceutical Sciences, Osaka University
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Nomura Masahiko
The Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Yasuda Satoshi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Naito Y
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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OKANIWA Yasushi
The Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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YUASA Shu
The Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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YAMAMOTO Nobuhiro
The Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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WATANABE Shiro
The Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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KOBAYASHI Tetsuyuki
The Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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OKUYAMA Harumi
The Department of Physiology, Saitama Medical School
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NAGATA Yutaka
The Department of Physiology, School of Medicine, Fujita Health University
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Okaniwa Yasushi
The Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
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Nakashima Y
Shimonoseki City Central Hospital Department Of Pediatrics
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Yamamoto Nobuhiro
The Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
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Watanabe Shiro
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University
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