Opioid Receptor Agonists Selective for μ and κ Receptors Attenuate Methamphetamine-Induced Behavioral Sensitization in the Mouse
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概要
- 論文の詳細を見る
The effects of intracerebroventricular (i.c.v.) injection of the μ-selective opioid receptor agonist [D-Ala^2,N-MePhe^4,Gly-ol] enkephalin (DAMGO) and the κ-selective opioid receptor agonist dynorphin A-(1-13) on the development of methamphetamine-induced behavioral sensitization in the mouse were determined using multidimensional behavioral analyses based upon a capacitance system. Methamphetamine (2mg/kg, s.c.) was administered to mice on 6 occasions at 3-or 4-d intervals. The methamphetamine-induced increase in linear locomotion and circling was markedly augmented by repeated administrations (3 or more times) of the drug, showing behavioral sensitization. Although repeated administrations of DAMGO (0.003 and 0.01μg, i.c.v.) or dynorphin A-(1-13) (3 and 12.5μg, i.c.v.) alone did not produce any significant effects on behavior, repeated administrations of DAMGO (0.003 and 0.01μg, i.c.v.) and dynorphin A-(1-13) (3 and 12.5μg, i.c.v.) attenuated the behavioral sensitization induced by methamphetamine (2mg/kg, s.c.). The attenuating effects of DAMGO (0.003 and 0.01μg, i.c.v.) and dynorphin A-(1-13) (3 and 12.5μg, i.c.v.) were fully reversed by withdrawal of these drugs for 3 weeks. Additionally, a single administration of DAMGO (0.003 and 0.01μg, i.c.v.) or dynorphin A-(1-13) (3 and 12.5μg, i.c.v.) alone did not produce any significant effects on behavior ; DAMGO (0.003 and 0.01μg, i.c.v.) and dynorphin A-(1-13) (3 and 12.5μg, i.c.v.) only attenuated the behavioral sensitization which had previously been developed by methamphetamine (2 mg/kg, s.c.). These results suggest that opioid receptor agonists selective for μ and κ receptors play an inhibitory role in the development of methamphetamine-induced behavioral sensitization.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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Ukai M
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Ukai Makoto
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Toyoshi Tohru
Nihon Bioresearch Inc.
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Toyoshi Tohru
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kameyama Tsutomu
Department Of Biology Faculty Of Science Ochanomiz University
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Kameyama Tsutomu
Dep. Of Chemical Pharmacology Fac. Of Pharmacy Meijo Univ.
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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