DESIGN OF A PHENCYCLIDINE IMPLANTATION PELLET : SUITABLE FOR TOLERANCE DEVELOPMENT

元データ 公益社団法人日本薬学会

概要

when using laboratory animals (e.g., mice) for phencyclidine (PCP) tolerance studies, an essential part of the procedure is to administer the PCP in such a way that the animals received adequate doses of the drug at frequent enough intervals to reach and main train the desired levels of tolerance or employ a osmotic minipump which is either suitable or convenient to develop a high degree of tolerance to PCP in a large number of animals in a short period. However, these methods are unfit for routine work because of repeated daily injections consume too much time and osmotic minipump comes expensive. Therefore, in this paper we attemped to develop PCP pellet suitable for tolerance development The s.c. implantation of a 10 or 20 mg PCP pellet in the back of a conscious mouse resulted in a much more rapid development of tolerance to PCP than that produced in mice receiving daily i.p. injection of, 10 or 20 mg/kg, PCP-HCL. Assessment of and degree of tolerance to PCP by PCP peller implantation and daily injection of PCP-HCL were evidenced by a degree of decrease in the duration of motor incoordination after the challenge with, 20 mg/kg, PCP-HCL 24 h after removal of PCP pellets or a last injection of PCP-HCL. These studies may demonstrate a substantial methodological improvement in producing a high degree of tolerance to PCP in a short period of time by means of the s.c. pellet implantation technique.

著者

Nabeshima Toshitaka Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
FURUKAWA Hiroshi Department of Surgery, Center for Adult Diseases
Nabeshima Toshitaka Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
Ho Ing.k. Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
KAMEYAMA TSUTOMU Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
Kameyama Tsutomu Faculty Of Pharmaceutical Sciences Nagoya City University
AMANO MANABU Department of Chemical Pharmacology and Department of Medicinal Chemistry, Faculty of Pharmaceutical
Amano Manabu Department Of Chemical Pharmacology Faculty Of Pharmacy Meijo University
Furukawa Hiroshi Dept. Chemical Pharmacology Fac. Of Pharmaceut. Sci. Meijo Univ.
Furukawa Hiroshi Department Of Plastic And Reconstructive Surgery Graduate School Of Medicine Hokkaido University
Kameyama Tsutomu Department Of Biology Faculty Of Science Ochanomiz University
Nabeshima Toshitaka Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
Furukawa Hiroshi Department Of Cardiology Okayama Central Hospital
Kameyama Tsutomu Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
Nabeshima Toshitaka Department Of Hospital Pharmacy School Of Medicine Nagoya University
Furukawa Hiroshi Department Of Applied Chemistry Faculty Of Engineering Nagasaki University

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