Synthesis and Antihypertensive Activity of 4-(Diazabicyclo[4.1.0]-heptenyloxy)benzopyran Derivatives and Their Analogues
スポンサーリンク
概要
- 論文の詳細を見る
A series of 3,4-dihydro-3-hydroxy-4-[(5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy]-2H-1-benzopyrans and their analogues were synthesized and evaluated on potassium channel opening and hypotensive activities. Compound (-)-13B with a (4-methyl-5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yl)oxy group for the 4-position of the benzopyran ring was 3 times as potent as EMD 57283 (II), the lead compound, in hypotensive activity. The results would demonstrate that 5-oxo-3,4-diazabicyclo[4.1.0]hept-2-en-2-yloxy moieties are effective as the substituents at the 4-position of benzopyran-type potassium channel openers.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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村田 隆史
阪大院薬
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Kubo H
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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Ohta M
Hiroshima Univ. Hiroshima Jpn
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KUBO Hajime
Faculty of Medicinal Chemistry; Hoshi University
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HORINO Haruhiko
New Product Research Laboratories II, Daiichi Pharmaceutical Company, Ltd.,
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MIMURA Tetsuya
New Product Research Laboratories II, Daiichi Pharmaceutical Company, Ltd.,
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OHTA Masahiro
New Product Research Laboratories II, Daiichi Pharmaceutical Company, Ltd.,
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KUBO Hideo
New Product Research Laboratories II, Daiichi Pharmaceutical Company, Ltd.,
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KITAGAWA Masayuki
New Product Research Laboratories II, Daiichi Pharmaceutical Company, Ltd.,
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KAGECHIKA Katsuji
New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.,
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Mimura T
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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Horino Haruhiko
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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Kitagawa M
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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Kagechika Katsuji
New Product Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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