Antinociceptive Effects of N-Acyloctahydropyrido[3,2,l-ij][1,6]naphthyridine in Mice : Structure-Activity Relation Study of Matrine-Type Alkaloids Part II
スポンサーリンク
概要
- 論文の詳細を見る
N-AcyIoctahydropyrido [3, 2, 1-ij] [1, 6] naphthyridincs were synthesized as derivatives of matrine-type alkaloids, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. The antinociceptive potencies of N-acyloctahydropyrido [3, 2, 1-ij] [1, 6] naphthyridines were significantly lower than those of (+)-matrine. The antinociceptive effects of N-benzyloctahydropyrido [3, 2, 1-ij] [1, 6] naphthyridines are approximately 5. 6 to 6. 5 times less than those of N-benzoyloctahydropyrido [3, 2, 1-ij] [1, 6] naphthyridine. These findings suggest that the amide group of matrine-type alkaloids is an essential functional group that influences antinociceptive potency. The antinociceptive effect of 4c was markedly antagonized by pretreatment with Naloxone, and that of 3c partially so.
- 社団法人日本薬学会の論文
- 2003-03-01
著者
-
Takizawa Masayuki
Faculty Of Medicinal Chemistry; Hoshi University
-
Takizawa Masayuki
星薬科大学
-
Takizawa Masayuki
Faculty Of Medicinal Chemistry Hoshi University
-
Kubo H
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
-
KOBASHI Seiichi
Faculty of Medicinal Chemistry; Hoshi University
-
KUBO Hajime
Faculty of Medicinal Chemistry; Hoshi University
-
YAMAUCHI Takayasu
Faculty of Medicinal Chemistry; Hoshi University
-
HIGASHIYAMA Kimio
Faculty of Medicinal Chemistry; Hoshi University
-
HIGASHIYAMA Kimio
Institute of Medicinal Chemistry, Hoshi University
-
Yamauchi T
Faculty Of Medicinal Chemistry; Hoshi University
-
Higashiyama Kimio
Institute Of Medicinal Chemistry Hoshi University
-
Higashiyama K
Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbAlc Values(Analytical Biochemistry)
- Antinociceptive Effects of N-Acyloctahydropyrido[3,2,l-ij][1,6]naphthyridine in Mice : Structure-Activity Relation Study of Matrine-Type Alkaloids Part II
- Study on Glutathionesulfonic Acid Sodium Salt as Biodistribution Promoter for Thiopental Sodium
- Study on Glutathionesulphonic Acid as Biodistribution Promoter : Concomitant Use Effect on Verapamil Hydrochloride and Tegafur
- Lupin Alkaloids from Chinese Maackia amurensis
- Lupin Alkaloids from Chinese Maackia Hupehensis
- (-)-14β-Acetoxymatrine and (+)-14α-Acetoxymatrine, Two New Matrine-Type Lupin Alkaloids from the Leaves of Sophora tonkinensis
- (-)-14β-Hydroxymatrine, a New Lupine Alkaloid from the Roots of Sophora tonkinensis
- The Survey of Trypanocidal Constituents in Some Mexican Plants
- Ursolic Acid as a Trypanocidal Constituent in Rosemary
- Trypanocidal Constituents in Plants 1. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in Guaco, Roots of Aristolochia taliscana
- Nematocidal Effects of Mexican-Medicinal Plant Extracts(Research note)
- Ursolic Acid as a Trypanocidal Constituent in Rosemary
- Conduritol F Glucosides and Terpenoid Glucosides from Cynanchum liukiuense and Distribution of Conduritol F Glucosides in Several Asclepiadaceous Plants
- Synthesis of(+)-Hupeol from(-)-Cytisine:Transformation of a Cyclic Imine into a Cyclic Hemiacetal
- A Lupin Alkaloid,(-)-Tenuamine(Norlusitanine),from Maackia tenuifolia
- Novel Potassium Channel Opener Prodrugs with a Slow Onset and Prolonged Duration of Action
- Synthesis and Antihypertensive Activity of 4-(Diazabicyclo[4.1.0]-heptenyloxy)benzopyran Derivatives and Their Analogues
- Automatic System for the Assay of Guanidino Compounds to Assess Uremic Status
- Automatic System for the Assay of Guanidino Compounds to Assess Uremic Status and Effect of Hemodialysis
- Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
- Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice(Medicinal Chemistry)
- Antinociceptive Effects of 1-Acyl-4-dialkylaminopiperidine and 1-Alkyl-4-dialkylaminopiperidine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids
- The Hypoglycemic Effect of (7R^*, 9aS^*)-7-Phenyl-octahydroquinolizin-2-one in Mice
- PD35 LUPIN ALKALOIDS IN THERMOPSIS SPECIES : NEW ALKALOIDS, STEREOCHEMICAL ASPECT AND METABOLISM IN TISSUE CULTURE
- Generation of Immortalized Murine Forebrain Cell Lines Expressing an α Isoform of Ca^/Calmodulin-Dependent Protein Kinase II
- Purification and Characterization of Active Fragment of Ca^/Calmodulin-Dependent Protein Kinase II from the Post-Synaptic Density in the Rat Forebrain^1
- Marstomentosides O-T, Polyxypregnane Glycosides from Marsdenia tomentosa
- Pregnane Glycosides from Marsdenia tomentosa
- Further Investigation of Phenanthroindolizidine Alkalodis from Tylophora tanakae
- Practical Synthesis of Optically Active Fluorine-substituted α-Phenylethylamines by Retardation of Hydrogenolytic Cleavage at Benzylic Position
- Stereospecific Reduction with Retention of Chiral Fluoral-derived 1, 3-Oxazolidines with LiAlH_4:Asymmetric Synthesis of 1-Substituted 2, 2, 2-Trifluoroethylamines
- Diastereoselective Addition of Grignard Reagents to Chiral 1,3-Oxazolidines Having a N-Diphenylmethyl Substituent