INHIBITION MECHANISMS OF STAUROSPORINE AND H7 TO cAMP-DEPENDENT PROTEIN KINASE THROUGH DOCKING STUDY

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概要

• 論文の詳細を見る

• Inhibition mechanisms of staurosporine and H7 to cAMP-dependent protein kinase have been investigated through docking studies. For each molecule, the energetically most stable docking model was searched by using the conformationally flexible automatic docking program ADAM without any presumptions. The results explain well the observation that staurosporine does not bind to the enzyme competitively with H7,even though the two compounds competitively inhibit ATP binding.

• 公益社団法人日本薬学会の論文
• 1996-03-15

著者

• ITAI Akiko

  Institute of Medicinal Molecular Design, Inc

• TOMIOKA Nobuo

  Institute of Medicinal Molecular Design

• Yamada Mizutani

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Itai Akiko

  Institute Of Medicinal Molecular Design

• TAKAGI Atsushi

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Takagi A

  Post Marketing Product Development Astellas Pharma Inc.

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